The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine1

Dancet, Eline; Brännström, Mats; Brasky, K.; Chai, Daniel; Chan, Anthony W.S.; Conn, P. Michael; Else, James G.; Falconer, Henrik; Fazleabas, A. T.; Farah, Idle O.; Goddeeris, Bruno; Golos, Thaddeus G.; Hau, Jann; Hearn, Jack; Kariuki, Thomas; Kyama, Cleophas; Lebovic, Dan I.; Mwenda, Jason M.; Ndung’u, Joseph Mathu; Nyachieo, Atunga; Parker, Joshua; Slayden, Ov D.; Stouffer, Richard L.; Strauss, Jerome F.; Taylor, Hugh S.; Vanderpoel, Sheryl; Westergaard, J.G.; Zelinski, Mary B.; D’Hooghe, Thomas

doi:10.1095/biolreprod.112.105908

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Animals and humans are biologically similar; therefore, they are susceptible to similar pathologies. Importantly, the World Medical Association Declaration of Helsinki states that all human clinical trials must be preceded by animal testing 6 , recognizing that animal models, including nonhuman primates, are important for understanding, diagnosing, and developing treatments for safe and effective use in human diseases 7 .…”

Section: Significance Of Animal Researchmentioning

confidence: 99%

Ethical Considerations in Animal Research: The Principle of 3R's

Dı́az¹,

Zambrano²,

Flores³

et al. 2021

RIC

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In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental animals has been indispensable. Animal research committees play a primary role in evaluating experimental research protocols, from their feasibility to the rational use of animals, but above all in seeking animal welfare. The Institutional Committee for the Care and Use of Animals (IACUC) has endeavored to share several relevant aspects in conducting research with laboratory animals. Here, we present and discuss the topics that we consider of utmost importance to take in the account during the design of any experimental research protocol, so we invite researchers, technicians, and undergraduate and graduate students to dive into the fascinating subject of proper animal care and use for experimentation. The main intention of these contributions is to sensitize users of laboratory animals for the proper and rational use of them in experimental research, as well as to disseminate the permitted and unpermitted procedures in laboratory animals. In the first part, the significance of experimental research, the main functions of IACUC, and the principle of the three R's (replacement, reduction, and refinement) are addressed.

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Section: Significance Of Animal Researchmentioning

confidence: 99%

Ethical Considerations in Animal Research: The Principle of 3R's

Dı́az¹,

Zambrano²,

Flores³

et al. 2021

RIC

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“…Lately, the UTx research has also come to include non-human primates, with their added advantage of a near human anatomy and physiology of the reproductive organs. The importance of primate models towards human application has lately been emphasized [54]. Thus, the higher non-human primates, such as the baboon and macaque, have a simplex uterus with a menstrual cycle that is almost identical to the human [55].…”

Section: Non-human Primates and Utx Researchmentioning

confidence: 99%

The Future of Human Uterus Transplantation

Johannesson

Dahm‐Kähler

Eklind

et al. 2014

Womens Health (Lond Engl)

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The only untreatable subgroup of female infertility is absolute uterine factor infertility (AUFI), which is due to congenital or surgical absence of a uterus or presence of a nonfunctional uterus. The solitary option for a woman with AUFI to become a biological mother today is through a gestational surrogate mother, a procedure that is prohibited in Sweden and large parts of the world. Uterus transplantation (UTx) is a potential future treatment of AUFI. After extensive animal research, also involving non-human primates, a small number of human UTx cases have recently been performed. Here, we summarize the primate UTx experiments that have paved the way for the human UTx cases, which are described and analyzed in more detail. We also estimate how many women of fertile age are affected by AUFI and describe the causes. The ethics around UTx is complex and is also addressed.

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Does Accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) Ensure Greater Compliance With Animal Welfare Laws?

Goodman¹,

Chandna²,

Borch

2014

Journal of Applied Animal Welfare Science

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Dogs are sometimes referred to as "man's best friend" and with the increase in urbanization and lifestyle changes, dogs are seen by their owners as family members. Society expresses specific concerns about the experimental use of dogs, as they are sometimes perceived to have a special status for humans. This may appear somewhat conflicting with the idea that the intrinsic value of all animals is the same, and that also several other animal species are used in biomedical research and toxicology. This aspect and many others are discussed in an introductory chapter dealing with ethical considerations on the use of dogs as laboratory animals. The report gives an overview on the use of dogs in biomedical research, safety assessment and the drug developmental process and reflects the discussion on the use of dogs as second (non-rodent)species in toxicity testing. Approximately 20,000 dogs are used in scientific procedures in Europe every year, and their distinct genetic, physiological and behavioral characteristics may support their use as models for e.g. behavioral analysis and genetic research. Advances in the 3Rs (Replacement, Reduction and Refinement of experiments using dogs) are described, potential opportunities are discussed and recommendations for further progress in this area are made.

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The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine1

Cited by 3 publications

References 32 publications

Ethical Considerations in Animal Research: The Principle of 3R's

Ethical Considerations in Animal Research: The Principle of 3R's

The Future of Human Uterus Transplantation

Does Accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) Ensure Greater Compliance With Animal Welfare Laws?

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