High-Density Silicone Oil Densiron-68 as an Intraocular Tamponade for Primary Inferior Retinal Detachments

Levasseur, Steve D.; Schendel, Steven; Machuck, Robert W. A.; Dhanda, Dhar

doi:10.1097/iae.0b013e3182725d49

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…Most studies about the use of HSO in complex retinal detachments report that the HSO remained in the eye for an average of 3 to 6 months [2, 9, 10, 21, 22]. We studied eyes with a poor prognosis due to complex retinal detachments and extensive inferior PVR.…”

Section: Discussionmentioning

confidence: 99%

Heavy Silicone Oil as a Long-Term Endotamponade Agent for Complicated Retinal Detachments

Guerra

Magalhães

Lucatto

et al. 2014

BioMed Research International

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We retrospectively evaluated a heavy silicone oil (HSO) as a long-term intraocular endotamponade agent to treat complicated RD by inferior PVR in 25 eyes of 25 patients. Patients underwent PPV and injection of Oxane HD as an internal tamponade agent. A comparison of preoperative and postoperative BCVA at month 1, month 6, and last visit was made in the group in which HSO was removed and in the group in which HSO was not removed. Statistical calculations were performed using the Wilcoxon test. The HSO was removed from 11 patients after a mean of 26.55 ± 21.38 months. The HSO remained inside the vitreous cavity in 14 eyes due to a high chance of PVR recurrence (mean follow-up period, 11.07 ± 7.44 months). Anatomic success was achieved in 92%. The BCVA in the group, in which HSO was not removed, improved significantly during the first 6 months. Among the patients who had the oil removed, there was improvement in BCVA after 1 month. Oil emulsification was the most common adverse effect in 52% of eyes. HSO is an effective tamponade in complex rhegmatogenous and tractional RD complicated by PVR. HSO can remain in the eye for long periods with relative tolerability and safety.

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Section: Discussionmentioning

confidence: 99%

Heavy Silicone Oil as a Long-Term Endotamponade Agent for Complicated Retinal Detachments

Guerra

Magalhães

Lucatto

et al. 2014

BioMed Research International

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“…In the literature the rate of emulsification is indicated with rates between 5% and 18.5% [9, 18, 24]. These studies have in common that smaller amounts of cases have been investigated in each study and the mean endotamponade duration was shorter compared to our study.…”

Section: Discussionmentioning

confidence: 65%

“…In previous studies the primary success rate has been determined between 54% and 89% [5–7, 9, 16–18]. The high range in these rates may be explained by heterogenous preoperative retinal findings that seem to be relevant especially in smaller case series.…”

Section: Discussionmentioning

confidence: 99%

Clinical Observations and Occurrence of Complications following Heavy Silicone Oil Surgery

Schwarzer

Mazinani

Plange

et al. 2014

BioMed Research International

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Purpose. To demonstrate development and complications in heavy silicone oil (HSO) surgery in 100 eyes following primary vitreoretinal surgery. Methods. 100 eyes were included in this retrospective study that underwent vitreoretinal surgery using HSO as endotamponade. Indication diagnoses were retinal detachments (n = 76), complicated macular holes (MH) (n = 20), and others (n = 4). HSO removal was performed after a mean period of 20.2 ± 19.0 weeks. In 18 eyes with poor functional prognosis the silicone oil remained permanently for stabilisation. Overall follow-up time was 35.9 ± 51.8 weeks. Results. The mean IOP before HSO surgery was 13.3 ± 5.6 mmHg and raised to an average maximum of 23.3 ± 8.5 mmHg postoperatively and decreased to 13.7 ± 7.2 mmHg after removal. Secondary IOP raise due to emulsification of the silicone oil endotamponade was seen in 29 eyes after 7.8 ± 4.5 weeks. Other complications being observed with HSO installed were persistent corneal erosion (n = 3) and prolonged anterior chamber inflammation (n = 29). In 13 eyes recurrent retinal detachments occurred during followup. Conclusions. According to our analysis HSO surgery might deliver satisfying results in complicated cases of ophthalmological surgery. However, potential complications should always be taken into account when making the decision if to use and when to remove HSO in complicated retinal surgery.

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“…The mixed compound generated, HSO, is currently used as postoperative intraocular tamponades,[ 38 39 ] however, the current literature still report OH in the postoperative period. [ 40 ] The results of this meta-analysis, according to the random model, lack of statistical significance. Nevertheless, it was possible to observe a trend for lower OH rate in SSO group [ Fig.…”

Section: Discussionmentioning

confidence: 96%

Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review

Romano

Cruciani²,

Semeraro

et al. 2015

Indian J Ophthalmol

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Aim:The intraocular silicone oil (SO) tamponades used in the treatment of retinal detachment (RD) have been associated with a difference ocular hypertension (OH) rate. To clarify, if this complication was associated to use of standard SO (SSO) versus heavy SO (HSO), we performed a systematic review and meta-analysis of comparative study between two kind of SO (standard or light vs. heavy) for the treatment of RD and macular hole, without restriction to study design.Materials and Methods:The methodological quality of two randomized clinical trials (RCTs) were evaluated using the criteria given in the Cochrane Handbook for Systematic Reviews of Intervention, while three non-RCTs were assessed with the Newcastle-Ottawa Scale and Strengthening the Reporting of Observational Studies in Epidemiology checklists. We calculated Mantel-Haenszel risk ratio (RR) with 95% confidence intervals (95% CIs). The primary outcome was the rate of patients with OH treated with SSO compared to HSO.Results:There were a higher number of rates of OH in HSO compared to SSO. This difference was statistically significant with the fixed effect model (Mantel-Haenszel RR; 1.55; 95% CI, 1.06–2.28; P = 0.02) while there was not significative difference with the random effect model (Mantel-Haenszel RR; 1.51; 95% CI, 0.98–2.33; P = 0.06).Conclusion:We noted a trend that points out a higher OH rate in HSO group compared to SSO, but this finding, due to the small size and variable design of studies, needs to be confirmed in well-designed and large size RCTs.

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High-Density Silicone Oil Densiron-68 as an Intraocular Tamponade for Primary Inferior Retinal Detachments

Abstract: High anatomical success rates can be achieved with primary vitrectomy for inferior rhegmatogenous retinal detachment with the use of Densiron-68.

Cited by 19 publications

References 24 publications

Heavy Silicone Oil as a Long-Term Endotamponade Agent for Complicated Retinal Detachments

Heavy Silicone Oil as a Long-Term Endotamponade Agent for Complicated Retinal Detachments

Clinical Observations and Occurrence of Complications following Heavy Silicone Oil Surgery

Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review

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