Risk of myocardial infarction in patients with rhinosinusitis

Hao, Wen Rui; Lin, Hui Wen; Chao, Pin Zhir; Wu, Chin Wen; Yen, Tze Hsun; Liu, Ju Chi; Liou, Tsan Hon

doi:10.1016/j.atherosclerosis.2012.10.058

Cited by 23 publications

(26 citation statements)

References 34 publications

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“…Chung et al also recently reported a comorbid association between CRSsNP and hypertension using cross‐sectional data. However, our findings on MIs and stroke contrast with prior work by Kan et al, who recently reported an increased risk of stroke within 5 years of a CRS diagnosis and Hao et al, who reported an increased risk of myocardial infarction within 3 years . There are a few possible explanations for the differences in our findings.…”

Section: Discussioncontrasting

confidence: 99%

Five‐year risk of incident disease following a diagnosis of chronic rhinosinusitis

Hirsch

Yan

Sundaresan

et al. 2015

Allergy

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Background Chronic rhinosinusitis (CRS) has a broad range of co-morbidities. Due to a lack of longitudinal studies, it is not known whether these co-morbidities cause CRS, are promoted by CRS, or share a systemic disease process with CRS. Objective To determine the risk of incident disease within five years after a new diagnosis of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). Methods We conducted a case-control study nested within the longitudinal cohort of primary care patients in the Geisinger Clinic using electronic health record data. We evaluated incident disease over 5 years in newly diagnosed CRSwNP and CRSsNP cases compared to controls using multivariable Cox regression models. Results CRSsNP (n=3612) cases were at greater risk (HR, 95% confidence interval) than controls for incidence of: upper airway diseases, including adenotonsillitis (3.29, 2.41–4.50); lower aerodigestive tract diseases, including asthma (2.69, 2.14–3.38); epithelial conditions, including atopic dermatitis (2.75, 1.23–6.16); and hypertension (1.38, 1.19–1.61). CRSwNP (n=241) cases were at greater risk for obesity than controls (1.74, 1.08–2.80), but CRSwNP was not associated with other diseases. Conclusion The risk of other diseases associated with CRS adds to the burden of an already highly burdensome condition, and suggests either that CRS promotes onset of other diseases or is an indicator of systemic disease processes. Different patterns of association with diseases by CRS phenotype may be due to CRSwNP sample size imitations or reflect a different pattern of disease onset by phenotype. These findings have implications for screening guidelines and care of CRS patients.

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Section: Discussioncontrasting

confidence: 99%

Five‐year risk of incident disease following a diagnosis of chronic rhinosinusitis

Hirsch

Yan

Sundaresan

et al. 2015

Allergy

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“…They say further study is needed, including in other ethnic groups. Their study is associated with similar reports in the same population showing CRS and 2 episodes of acute sinusitis may increase the risk for myocardial infarction.…”

Section: Discussionsupporting

confidence: 81%

Incidental paranasal sinusitis on routine brain magnetic resonance scans: association with atherosclerosis

Rosenthal

Lundy

Massoglia

et al. 2016

Int Forum Allergy Rhinol

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“…) including upper and lower respiratory tract infections are established risk factors for acute coronary syndrome (Hao et al . ). In acute infections, bacterial toxins may activate the innate immune system (Hotchkiss & Karl ) and initiate intravascular inflammation and thrombosis and consequently may contribute to cardiac events (Cotti et al .…”

Section: Introductionmentioning

confidence: 97%

“…Chronic oral infections including periodontitis (Beck et al 1996) have been associated with increased risk of CVD and a healthy dentition as a marker for reduced past oral infections has been associated with a significantly lower risk of CVD mortality (Janket et al 2014). Acute infections (Corrales-Medina et al 2013) including upper and lower respiratory tract infections are established risk factors for acute coronary syndrome (Hao et al 2013). In acute infections, bacterial toxins may activate the innate immune system (Hotchkiss & Karl 2003) and initiate intravascular inflammation and thrombosis and consequently may contribute to cardiac events (Cotti et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population

et al. 2017

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Risk of myocardial infarction in patients with rhinosinusitis

Cited by 23 publications

References 34 publications

Five‐year risk of incident disease following a diagnosis of chronic rhinosinusitis

Five‐year risk of incident disease following a diagnosis of chronic rhinosinusitis

Incidental paranasal sinusitis on routine brain magnetic resonance scans: association with atherosclerosis

Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population

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