Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass

“…An important aspect of this process is mitochondrial turnover, which refers to the integrated processes of degradation via autophagy (mitophagy) and biogenesis. We and others previously demonstrated the importance of cardiac mitophagy in attenuating I/R-induced injury (2)(3)(4). A considerable amount of preclinical evidence that mitochondrial biogenesis programs are activated in the setting of cold cardioplegia or I/R has been reported (reviewed in ref.…”

Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids

“…It should be noted that our data are coherent with previous studies in other types of muscle cells. For instance, PINK1 deficientmice had enhanced oxidative stress and higher degrees of cardiomyocyte apoptosis [33] Kubli and coworkers [34] showed that mice with global deletion of Parkin were more sensitive to myocardial infarction, which was mainly attributed to the impaired mitophagy in cardiomyocytes. In skeletal muscle cells the removal of drosophila PINK1 resulted in muscle degeneration through an apoptotic mechanism [35,36].…”

Sterile Inflammation and Degradation Systems in Heart Failure

“…77 PARK2-deficient mice show only mild phenotypes regarding behaviour 78, 79 and normal cardiac function, but disorganized and smaller mitochondria in the heart under basal conditions. 80 Regarding 86 in mammals localize on the outer membrane and promote mitophagy by directly binding to components of the autophagy machinery, such as Atg8 in yeast or LC3 in mammals. NIX/BNIP3L is involved in specific types of mitophagy for mitochondrial elimination from reticulocytes.…”