Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case–control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65–0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55–0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68–1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88–1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73–1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk

show abstract

“…29 We also repeated analyses among HBV/HCV-negative participants. p-Values<0.05 were considered statistically significant.…”

Section: Statistical Analysesmentioning

confidence: 99%

Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Duarte‐Salles

Fedirko

Stępień

et al. 2015

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…In addition to insulin, high blood glucose is recently proposed to be a new link between DM and cancer and it may explain how DM increases the risk of CCA [31,32]. A supra-physiological range of glucose can enhance the Wnt/b-catenin signaling pathway which activates transcription of molecules involved in the cell cycle and cell proliferation in both malignant and non-malignant cell lines (Fig.…”

Section: A Possible Molecular Linkage Of Dm and Ccamentioning

confidence: 99%

Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma

Saengboonmee

Seubwai

Wongkham

et al. 2015

Cancer Epidemiology

View full text Add to dashboard Cite

“…Diabetes mellitus (DM) has been reported to be associated with risk and prognosis of many cancer types, including CCA (6,7). The molecules that bridge DM and cancer have been shown to be insulin and a high blood glucose level (8)(9)(10). Repositioning an antidiabetic compound that appears to have great potential for cancer prevention and as a cure provides a rare opportunity.…”

mentioning

confidence: 99%

Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB

Saengboonmee

Seubwai

Cha’on

et al. 2017

View full text Add to dashboard Cite

show abstract

Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans

Abstract: Findings suggest that higher consumption of dietary fiber and lower consumption of total sugars are associated with lower HCC risk. In addition, high dietary fiber intake could be associated with lower IBD cancer risk.

Cited by 104 publications

References 50 publications

Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma

Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB

Contact Info

Product

Resources

About