Accuracy of colposcopy management to detect CIN3 and invasive cancer in women with abnormal screening tests: Results from a primary HPV screening project from 2006 to 2011 in Wolfsburg, Germany

Petry, Karl Ulrich; Luyten, Alexander; Scherbring, Sarah

doi:10.1016/j.ygyno.2012.10.017

Cited by 34 publications

(34 citation statements)

References 24 publications

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“…The review of abstracts yielded eleven papers that were reviewed by panel members [5][6][7][8][9][10][11][12][13][14][15]. In addition, significant papers published prior to November 2011 were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance

Huh

Ault

Chelmow

et al. 2015

Gynecologic Oncology

484

573

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Section: Methodsmentioning

confidence: 99%

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance

Huh

Ault

Chelmow

et al. 2015

Gynecologic Oncology

484

573

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“…Current biopsy procedures rely on visual features to identify the area on the cervix that most likely represents the worst lesion. [4][5][6][7][8] However, colposcopy has a sensitivity of 50-70% to detect CIN2+. [9][10][11][12][13] Gains in sensitivity can be obtained by increasing the number of biopsies.…”

Section: Introductionmentioning

confidence: 99%

The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

Marel

Baars

Quint

et al. 2014

BJOG

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Objective To study colposcopic performance in diagnosing high-grade cervical intraepithelial neoplasia or cervical cancer (CIN2+ and CIN3+) using colposcopic characteristics and high-risk human papillomavirus (hrHPV) genotyping.Design Cross-sectional multicentre study.Setting Two colposcopy clinics in The Netherlands and Spain.Population Six hundred and ten women aged 17 years and older referred for colposcopy because of abnormal cytology.Methods A cervical smear was obtained. Colposcopists identified the worst lesion, graded their impression and scored the colposcopic characteristics of the lesions. Up to four biopsies were collected, including one biopsy from visually normal tissue.Main outcome measures CIN2+ and CIN3+, positive for HPV16 or other high-risk HPV types (non-16 hrHPV-positive).Results The mean age in HPV16-positive CIN2+ women was 35.1 years compared with 39.1 years in women with other hrHPV types (P = 0.002). Sensitivity for colposcopy to detect CIN2+ was 87.9% (95%CI 83.2-91.5), using colposcopic cut-off of 'any abnormality'. The remaining CIN2+ were found by a biopsy from visually normal tissue or endocervical curettage (ECC Conclusions In this population following European screening practice, HPV16-related CIN2+ lesions were detected at younger age and showed similar colposcopic impression as non-16 hrHPV high-grade lesions. There was no relationship between any of the colposcopic characteristics and HPV16 status.Keywords Cervical intraepithelial neoplasia, colposcopy, genotyping, HPV16, human papillomavirus.Please cite this paper as: van der Marel J, van Baars R, Quint WGV, Berkhof J, del Pino M, Torn e A, Ordi J, Wentzensen N, Schiffman M, van de Sandt MM, Lindeman J, Jenkins D, Helmerhorst TJM, Verheijen RHM, ter Harmsel B, Alonso I. The impact of human papillomavirus genotype on colposcopic appearance: a cross-sectional analysis.

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“…In addition, the significance of double stain in the case of women below the age of 30 was equally valid as for women over 30 years of age. In two further studies, for the triaging of HPV-positive women, cytologically negative women, and women with cytological suspicion of low-grade CIN, double stain was equal or superior to HPV DNA testing [53,54]. An additional advantage of a test system such as double stain is that the existing technological infrastructure for cytological screenings can be used and modified.…”

Section: Cervical Cancer Screening: Commentmentioning

confidence: 99%

Benefits and Risks of Cervical Cancer Screening

2014

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Accuracy of colposcopy management to detect CIN3 and invasive cancer in women with abnormal screening tests: Results from a primary HPV screening project from 2006 to 2011 in Wolfsburg, Germany

Cited by 34 publications

References 24 publications

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance

The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

Benefits and Risks of Cervical Cancer Screening

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