A single nucleotide polymorphism of interleukin‐6 gene is related to plasma adrenomedullin levels

Wong, Heung‐wah; Leung, R; Lam, Tai Hing; Thomas, G. Neil; Lam, Karen S.L.; Cheung, Bernard M Y

doi:10.1111/cen.12078

Cited by 6 publications

(3 citation statements)

References 32 publications

(65 reference statements)

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“…The rs1800796 SNP is located in the IL-6 promoter and has been thought to be associated with adult TB in Chinese population recently [9]. The tag-SNP rs17147230 was thought to be functionally associated with plasma adrenomedullin levels by one research group [18]. Meanwhile, 10 tag-SNPs of IL-6R were included in our genotyping.…”

Section: Resultsmentioning

confidence: 99%

A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis

Shen

Sun

et al. 2014

BioMed Research International

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Background. IL-6 is a proinflammatory cytokine that plays a critical role in host defense against tuberculosis (TB). Genetic polymorphisms of IL-6 and its receptor IL-6R had been discussed in adult TB recently. However, their role in pediatric TB is still unclear. Due to the obvious differences in TB pathophysiology in children, which may also reflect differences in genetic background, further association studies in pediatric populations are needed. Methods. A case-control study was carried out in a Chinese pediatric population including 353 TB patients and 400 healthy controls. Tag-SNPs of IL-6 and IL-6R genes were selected by Haploview software, genotyped using MassArray, and analyzed statistically. Results. One polymorphism, rs2229238, in the 3'UTR region of IL-6R was observed to be associated with increased resistance to TB (adjusted P = 0.03). The rs2229238 T allele contributed to a reduced risk to TB in recessive heritable model (OR, 0.53; 95% CI, 0.35–0.78). Conclusions. By tag-SNP genotyping based case-control study, we identified a genetic polymorphism in the IL-6R 3'UTR that regulates host resistance to pediatric TB in a Chinese population.

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Section: Resultsmentioning

confidence: 99%

A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis

Shen

Sun

et al. 2014

BioMed Research International

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“…Preclinical [ 42 – 44 ] and clinical data [ 45 ] point towards a modulating effect of ADM on IL-6 under different inflammatory conditions. Furthermore, plasma ADM levels have been found to be related to a single nucleotide polymorphism of the IL6 gene [ 46 ]. In the present study, we observed that addition of IL-6 to the multivariable model attenuated the association between MR-proADM and all-cause mortality, although the association remained significant.…”

Section: Discussionmentioning

confidence: 99%

Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study

et al. 2022

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Background and aim Despite its vasodilatory effect, adrenomedullin and its surrogate mid-regional pro-adrenomedullin (MR-proADM) have been found to be positively associated with all-cause and cardiovascular mortality. However, the underlying mechanisms thereof remain unclear and the associations were mostly shown in geriatric cohorts or in patients with chronic diseases. Therefore, we aimed to investigate the possible involvement of abdominal obesity, selected adipokines, and biomarkers of subclinical inflammation in the association of MR-proADM with mortality in a population based study cohort. Methods Prospective analysis of the KORA F4 study; median follow-up 9.1 (8.8–9.4) years. Complete data on MR-proADM and mortality was available for 1551 participants, aged 56.9±12.9 years (mean±SD). Correlation and regression analyses of MR-proADM with overall (BMI) and abdominal obesity (waist circumference), selected adipokines and biomarkers of subclinical inflammation. Cox proportional hazard models on the association of MR-proADM with all-cause and cardiovascular mortality with adjustment for cardiovascular risk factors and selected biomarkers in study subgroups (n = 603–1551). Results MR-proADM associated with all-cause (HR (95%CI): 2.37 (1.72–3.26) and 2.31 (1.67–3.20)) and cardiovascular mortality (4.28 (2.19–8.39) and 4.44 (2.25–8.76)) after adjustment for traditional cardiovascular risk factors including BMI or waist circumference, respectively. MR-proADM was further associated with four out of seven examined adipokines (leptin, retinol-binding protein-4, chemerin, and adiponectin) and with five out of eleven examined biomarkers of subclinical inflammation (high-sensitivity C-reactive protein, interleukin-6, myeloperoxidase, interleukin-22, and interleukin-1 receptor antagonist) after multivariable adjustment and correction for multiple testing. However, only IL-6 substantially attenuated the association of MR-proADM with all-cause mortality. Conclusions We found an association of MR-proADM with (abdominal) obesity, selected adipokines, and biomarkers of subclinical inflammation. However, the association of MR-proADM with mortality was independent of these parameters. Future studies should investigate the role of IL-6 and further characteristics of subclinical inflammation in the association between MR-proADM and all-cause mortality.

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“…In addition, circulating AM levels could be modified by mutations in other genes; such as an exonic insertion/deletion polymorphism in an intermedin gene [38], a SNP in IL-6 gene [39], or a SNP in adiponectin gene [40]. Interestingly, the carriers of these mutations show a higher genetic predisposition to develop some pathologies related to AM such as hypertension, renal dysfunction, dysglycemia, or even cerebrovascular disease.…”

Section: Adrenomedullin Synthesis Release and Metabolismmentioning

confidence: 99%