Serial Changes in Glucose-Loaded ¹⁸F-Fluoro-2-Deoxyglucose Positron Emission Tomography, ^99mTc-Tetrofosmin and ¹²³I-Beta-Methyl-p-Iodophenyl-Penta-Decanoic Acid Myocardial Single-Photon Emission Computed Tomography Images in Patients With Anterior Acute Myocardial Infarction

Abstract

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp he energy metabolism of the heart and the utilization of substrates including glucose, fatty acids, amino acids, lactic acid and ketone bodies depend on circumstances, 1 and are primarily based on fatty acid metabolism and glucose metabolism in a competitive manner. 2 However, a shift to anaerobic metabolism because of low oxygen supplies causes ischemic myocardium to primarily utilize glucose. 3,4 Many reports have discussed whether maintaining glucose metabolism is important in estimating the viability of ischemic myocardium, and some reports indicate that improvements in left ventricular function and the prevention of cardiac events are achieved with the use of aggressive revascularization procedures. 5-9 The use of glucose-loaded 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) PET has played a central role in helping cardiovascular interventionalists decide whether revascularization procedures are indicated in patients with old myocardial infarction (MI) with residual stenosis and angina pectoris. 10-13 18 F-FDG-PET has been also utilized to evaluate systemic inflammatory diseases, including malignancies, because 18 F-FDG accumulates in sites of inflammation. 14,15 Therefore, appropriate timing for the evaluation of glucose-loaded 18 F-FDG-PET images of acute MI (AMI) has been conventionally considered T

Diagnosis and Detection of Myocardial Injury in Active Cardiac Sarcoidosis – Significance of Myocardial Fatty Acid Metabolism and Myocardial Perfusion Mismatch –

“…9 This phenomenon is based more on severely damaged fatty acid metabolism as "ischemic memory" than upon perfusion injury caused by myocardial ischemia. 10, 11 The uptake of BMIPP was found to be more impaired than that of the myocardial perfusion tracer, thallium-201 (TL) in patients with CS, 12 but only a low number of patients were assessed in that study.…”

The clinical utility of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography in guiding myocardial revascularisation

“…As such, PCI should be reserved for symptomatic patients with positive angina symptoms while on optimal doses of guideline-recommended medical therapy [41]. Our literature review found a large body of studies where patients referred for viability imaging with PET were subjected to PCI [22,38,[42][43][44][45][46][47][48][49][50].…”

How Should Myocardial Viability Be Assessed by¹⁸F-Fluoro-2-Deoxyglucose Positron Emission Tomography?

“…2 In particular, the size of the defect on FDG is considerably larger in the acute than the chronic phase. Others have reported similar findings.…”