Clinical Significance of Interleukin 33 (IL-33) in Patients with Eosinophilic Pneumonia

Mato, Naoko; Bando, Masashi; Kusano, Aya; Hirano, Toshikatsu; Nakayama, Masayuki; Uto, Tomohiro; Nakaya, Takakiyo; Yamasawa, Hideaki; Sugiyama, Yukihiko

doi:10.2332/allergolint.12-oa-0439

Cited by 35 publications

(27 citation statements)

References 35 publications

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“…The serum and BAL levels of IL-33 were significantly higher in patients with acute eosinophilic pneumonia than in chronic eosinophilic pneumonia. 90 Consistent with this study, Ampawong et al recently demonstrated that bronchial IL-33 levels were increased in severe malaria patients with lung injury. 91 Acute Plasmodium falciparum infection increased eosinophil activity, 92 suggesting that IL-33 may play a role in lung injury with eosinophilic lung inflammation.…”

Section: Il-33/st2 In Alisupporting

confidence: 89%

Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases

Zhao

2015

Crit Rev Immunol

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Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It modulates immune responses and biological functions through binding to its membrane receptor, ST2L. ST2L is a member of the Toll-like/IL-1 (TIR)–receptor superfamily, and its isoform, soluble ST2 (sST2), functions as an inhibitor of the IL-33/ST2L pathway. Levels of IL-33 and sST2 in serum and bronchoalveolar lavage fluid (BAL) are known biomarkers for a variety of disorders such as heart failure, non-small-cell lung cancer, and pulmonary inflammatory diseases. IL-33 also exists in the nuclei, and nuclear IL-33 seems to regulate cytokine gene expression. In this review, we focus on the role of IL-33/ST2 in the pathogenesis of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung injury.

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Section: Il-33/st2 In Alisupporting

confidence: 89%

Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases

Zhao

2015

Crit Rev Immunol

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“…The serum IL-5 level decreased to zero after 10 days of treatment, even in one patient whose level was as high as 2448.0 pg/mL upon initial presentation. IL-5 is a specific cytokine that plays important roles in the recruitment, degranulation, and survival of eosinophils, and previous studies have demonstrated elevated IL-5 levels in both the serum and BAL fluid of patients with active AEP [13,15]. However, previous studies did not show serial changes with clinical improvement.…”

Section: Discussionmentioning

confidence: 89%

Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia

Jhun

Kim

et al. 2014

Respiratory Medicine

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“…The concentration of IL-33, an epithelial cell-derived cytokine, in response to nonspecific stimuli and involved in innate immune response [35-37], is upregulated in BALF of EP patients [25, 26]. IL-33 can activate type 2 innate lymphoid cells (ILC2) to produce IL-5 or IL-13 [35, 36, 38], thereby inducing periostin.…”

Section: Discussionmentioning

confidence: 99%

“…As for the degree of cytokine/chemokine production in the airway, several reports suggest that the cytokine/chemokine concentrations are higher in AEP than in CEP, although the BALF eosinophil count of both is similar [20-26]. In fact, the IL-5 and IL-13 concentrations in BALF have been shown to be higher in AEP than in CEP [20-25]. Furthermore, compared with CEP, in AEP there is upregulated airway production of chemokines (e.g., eotaxin) for the activation of eosinophils, and of epithelial cell-derived cytokines (including IL-33) for the induction of the T2 response [23-26].…”

Section: Introductionmentioning

confidence: 99%

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

Nakagome

Nakamura

Kobayashi

et al. 2019

Int Arch Allergy Immunol

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Background: Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP. Methods: BAL was performed in healthy volunteers and in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), and sarcoidosis. The periostin concentrations in the BALF were measured. Results: The periostin concentration in the BALF increased significantly with pulmonary eosinophil ia and was higher in AEP and CEP patients than in healthy volunteers and sarcoidosis patients, even after adjusting the albumin concentration. In pulmonary eosinophilia, the periostin concentration correlated with the eosinophil and lymphocyte counts, the concentration of albumin, and the concentration of cytokines such as IL-5, IL-13, and transforming growth factor β1. Conclusions: Although some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.

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Clinical Significance of Interleukin 33 (IL-33) in Patients with Eosinophilic Pneumonia

Abstract: The remarkable increase of BALF IL-33 in AEP indicated the local production of IL-33 in lungs. IL-33 is considered to be a local key molecule for triggering pulmonary eosinophilia, together with IL-5. BALF IL-33 appears to be a useful marker for discriminating AEP from CEP and ARDS.

Cited by 35 publications

References 35 publications

Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases

Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases

Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

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