23–valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial

French, Neil; Nakiyingi, Jessica; Carpenter, L. J.; Lugada, Eric; Watera, Christine; Moi, Khoo Yok; Moore, Michael K.; Antvelink, D; Mulder, Daan W.; En, Janoff; Whitworth, James; Gilks, Charles F.

doi:10.1016/s0140-6736(00)02377-1

Cited by 431 publications

(272 citation statements)

References 23 publications

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“…Due to the severe disease burden and mortality, the emergence of drug-resistant clinical isolates (14,36), the lack of a universally effective vaccine (17,39), and an increase in the number of immunocompromised patients, it is increasingly important to understand the pathogenic processes of pneumococcal disease in order to develop novel therapeutic modalities and an effective vaccine.…”

mentioning

confidence: 99%

Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection withStreptococcus pneumoniaeIn Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

et al. 2008

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Pneumolysin is a pore-forming cytolysin known as a major virulence determinant of Streptococcus pneumoniae. This protein toxin has also been shown to activate the Toll-like receptor 4 (TLR4) signaling pathway. In this study, a mutant S. pneumoniae strain deficient in pneumolysin (⌬ply) and a recombinant pneumolysin protein (rPLY) were constructed. Upon infection of macrophages in vitro, the ability to induce the production of interleukin-1␣ (IL-1␣), IL-1␤, and IL-18 was severely impaired in the ⌬ply mutant, whereas there was no marked difference in the induction of tumor necrosis factor alpha (TNF-␣) and IL-12p40 between the wild type and the ⌬ply mutant of S. pneumoniae. When macrophages were stimulated with rPLY, the production of IL-1␣, IL-1␤, and IL-18 was strongly induced in a TLR4-dependent manner, whereas lipopolysaccharide, a canonical TLR4 agonist, hardly induced these cytokines. In contrast, lipopolysaccharide was more potent than rPLY in inducing the production of TNF-␣, IL-6, and IL-12p40, the cytokines requiring no caspase activation. Activation of caspase-1 was observed in macrophages stimulated with rPLY but not in those stimulated with lipopolysaccharide, and the level of activation was higher in macrophages infected with wild-type S. pneumoniae than in those infected with the ⌬ply mutant. These results clearly indicate that pneumolysin plays a key role in the host response to S. pneumoniae, particularly in the induction of caspase-1-dependent cytokines.

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confidence: 99%

Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection withStreptococcus pneumoniaeIn Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

et al. 2008

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“…30 However, in a randomized placebo-controlled study, an increase of all-cause pneumonia was observed in the vaccine group; the mortality rate in both groups remained similar. 31 In 2010, a review of studies on the clinical efficacy of the non-conjugated polysaccharide vaccine in HIV-infected adults did not yield any definitive evidence of a reduction in pneumonia and pneumococcal infection. 32 The loss of the antibodies induced by the nonconjugated polysaccharide vaccine occurs particularly rapidly in the most severely immunocompromised patients or in patients not (Continued on next page) virologically controlled by cART.…”

Section: Pneumococcal Vaccinationmentioning

confidence: 99%

Immunization of HIV-infected adult patients — French recommendations

Frésard

Gagneux‐Brunon

Lucht

et al. 2016

Human Vaccines & Immunotherapeutics

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Human immunodeficiency virus (HIV)-infected patients remain at increased risk of infection including vaccine-preventable diseases. Vaccines are therefore critical components in the protection of HIV-infected patients from an increasing number of preventable diseases. However, missed opportunities for vaccination among HIV-infected patients persist and vaccine coverage in this population could be improved. This article presents the French recommendations regarding immunization of HIV-infected adults in the light of the evidence-based literature on the benefits and the potential risks of vaccines among this vulnerable population.

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“…Bei immunsupprimierten Patienten, z.B. bei Patienten mit HIV-Infektion war sogar ein negativer E ekt der Polysaccharidimpfung zu beobachten [6].…”

Section: Pneumokokken Sind Stark Pathogenunclassified

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23–valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial

Cited by 431 publications

References 23 publications

Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection withStreptococcus pneumoniaeIn Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection withStreptococcus pneumoniaeIn Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

Immunization of HIV-infected adult patients — French recommendations

Effektiv vorbeugen ist besser als heilen

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