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Guida, A.; Towler, Mark R.; Wall, J. Gerard; Hill, Robert G.; Eramo, Stefano

doi:10.1023/a:1025794927195

Cited by 86 publications

(23 citation statements)

References 6 publications

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“…The strontium included in cement B was not found to increase the antibacterial effects of the cements, even though it has previously been shown to be inhibitory to bacterial growth when incorporated into similar materials [3]. In the previous published analysis, however, strontium concentrations were considerably higher than those investigated in this work, which may account for the discrepancy.…”

Section: Antibacterial Activity Of Cementscontrasting

confidence: 76%

“…The antibacterial activity of the cements was evaluated against the oral bacterial species S. mutans (American Type Culture Collection, ATCC, 25175) and A. viscosus (ATCC 19246), using the agar disc-diffusion method [3]. The bacteria were grown from stock cultures on brain heart infusion (BHI) agar at 37°C for 16 h and isolated colonies were used to seed fresh cultures in 10 ml Luria Broth (LB).…”

Section: Agar Disc-diffusion Testmentioning

confidence: 99%

“…However, PMMA can impair the correct functioning of the immune system, leading to a safe haven for the proliferation of contaminating bacteria around cemented prostheses [1] and thereby contributing to the 7% of hip revision surgeries caused by primary deep infection [2]. Glass polyalkenoate cements (GPCs), commonly used in dentistry, are recognised for their ability to prevent secondary caries through the release of antibacterial agents such as fluoride and strontium [3]. However, the presence of aluminium in the glass phase of commercially available GPCs has restricted their use in orthopaedics as aluminium is believed to cause defective bone mineralisation [4,5] and has been implicated in the pathogenesis of degenerative brain diseases such as Parkinson's and Alzheimer's disease [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements

Boyd

Tanner

et al. 2006

J Mater Sci: Mater Med

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118

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Zinc-based glass polyalkenoate cements have been synthesised and their potential use in orthopaedic applications investigated. Zinc ions were released from the materials in a rapid burst over the first 24 h after synthesis, with the release rate falling below detectable levels after 7 days. Cement-implanted bone samples were prepared and the released zinc was shown, using energy dispersive X-ray analysis, to penetrate from the cement into the adjacent bone by up to 40 µm. Finally, the cements exhibited antibacterial activity against Streptococcus mutans and Actinomyces viscosus that reflected the pattern of zinc release, with the inhibition of growth greatest shortly after cement synthesis and little or no inhibition measureable after 30 days.

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Section: Antibacterial Activity Of Cementscontrasting

confidence: 76%

Section: Agar Disc-diffusion Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements

Boyd

Tanner

et al. 2006

J Mater Sci: Mater Med

Self Cite

118

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“…Fluoride plays an important biological role, particularly in dentistry, and has the effect of improving the resistance of the tooth material to acid attack, decreasing demineralization and increasing remineralization, inhibiting dental decays, and making the cement translucent [144][145][146]. Although the therapeutic activity of CGPCs depends mainly on the glass phase [144,[147][148][149][150], the polymer phase plays an important role in attacking the glass cations and releasing them or complexing them within its network. PAA or copolymers of acrylic and itaconic or maleic acid have been the most commonly used polymers in the preparation of GPCs.…”

Section: Ion Releasementioning

confidence: 99%

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Alhalawani

Curran

Boyd

et al. 2015

Journal of Polymer Engineering

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Abstract Glass polyalkenoate cements (GPCs) have been used in dentistry for over 40 years. These novel bioactive materials are the result of a reaction between a finely ground glass (base) and a polymer (acid), usually poly(acrylic acid) (PAA), in the presence of water. This article reviews the types of PAA used as reagents (including how they vary by molar mass, molecular weight, concentration, polydispersity and content) and the way that they control the properties of the conventional GPCs (CGPCs) formulated from them. The article also considers the effect of PAA on the clinical performance of CGPCs, including biocompatibility, rheological and mechanical properties, adhesion, ion release, acid erosion and clinical durability. The review has critically evaluated the literature and clarified the role that the polyacid component of CGPCs plays in setting and maturation. This review will lead to an improved understanding of the chemistry and properties of the PAA phase which will lead to further innovation in the glass-based cements field.

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“…Several commercial dental GIC contain strontium in the glass component (Stamboulis et al, 2004), and the release of strontium ions has been shown to enhance tooth remineralization (Thuy et al, 2008) and promote antibacterial properties (Guida et al, 2003;Brauer et al, 2013), particularly in synergy with fluoride ions (Dabsie et al, 2009). Furthermore, strontium ions are known to enhance osteoblastic bone formation and reduce osteoclastic bone resorption (Marie et al, 2001), and they are used for the treatment of osteoporosis (Marie, 2005).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Ion-Releasing Bioactive Glass Ionomer Cements with Improved Mechanical Strength and Radiopacity

et al. 2015

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Bioactive glasses (BG) are used to regenerate bone, as they degrade and release therapeutic ions. Glass ionomer cements (GIC) are used in dentistry, can be delivered by injection, and set in situ by a reaction between an acid-degradable glass and a polymeric acid. Our aim was to combine the advantages of BG and GIC, and we investigated the use of alkali-free BG (SiO2-CaO-CaF2-MgO) with 0-50% of calcium replaced by strontium, as the beneficial effects of strontium on bone formation are well documented. When mixing BG and poly(vinyl phosphonic-co-acrylic acid), ions were released fast (up to 90% within 15 min at pH 1), which resulted in GIC setting, as followed by infrared spectroscopy. GIC mixed well and set to hard cements (compressive strength up to 35 MPa), staying hard when in contact with aqueous solution. This is in contrast to GIC prepared with poly(acrylic acid), which were shown previously to become soft in contact with water. Strontium release from GIC increased linearly with strontium for calcium substitution, allowing for tailoring of strontium release depending on clinical requirements. Furthermore, strontium substitution increased GIC radiopacity. GIC passed ISO10993 cytotoxicity test, making them promising candidates for use as injectable bone cements.

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Untitled

Cited by 86 publications

References 6 publications

The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements

The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Therapeutic Ion-Releasing Bioactive Glass Ionomer Cements with Improved Mechanical Strength and Radiopacity

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