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Gevorgyan, G. A.; Isakhanyan, A. U.; Papoyan, O. A.; Tumadzhyan, A. E.

doi:10.1023/a:1024594800004

Cited by 5 publications

(7 citation statements)

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“…1 H NMR spectra were taken on a Varian Mercury-300 in DMSO-d 6 with tetramethylsilane as internal standard. Compound purity was monitored on Silufol UV-254 plates developed in a system consisting of butanol, ethanol, acetic acid, and water (8:2:1:3) and revealed with iodine vapor.…”

Section: Experimental Chemical Sectionmentioning

confidence: 99%

“…Continuing our studies on the synthesis of aminopropanols [1][2][3][4][5] by reduction of b-amino-4-substituted propiophenones IIa -h, we have synthesized a series of 1-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]-propan-1-ols (IIIa -h) with conversion to their dihydrochlorides (IVa -h). Reduction of 1-(4-substituted phenyl)-3-(4-carbethoxypiperazin-1-yl)propan-1-ones (IIi -k) with lithium alumohydride in absolute ether to 1-(4-substituted phenyl)-3-(4methylpiperazin-1-yl)propan-1-ols (IIIi -k) with subsequent conversion to dihydrochlorides (IVi -k) was also performed.…”

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confidence: 99%

“…Substituted phenyl-b-aminopropiophenones (II) were prepared as described in[1].1[(4-Substituted phenyl)-3-(4-substituted piperazino(piperidino)]propan-1-ols (IIIa -k). Aminoketones II (0.01 mol) in absolute ether were added dropwise to suspensions of 0.99 g (0.025 mol) of lithium alumohydride in 20 ml of absolute ether with mixing.…”

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confidence: 99%

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Synthesis of 2-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]propan-1-ol dihydrochlorides and their effects on adenosine deaminase activity

et al. 2011

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Aminomethylation of 4-substituted acetophenones yielded a series of b-amino-4-substituted propiophenones. Reduction of these with lithium alumohydride in dry ether produced 1-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]propan-1-ols, which were then converted to the corresponding dihydrochlorides. The abilities of these compounds to inhibit adenosine deaminase, a key enzyme in purine metabolism in living organisms, were studied. Some of the compounds had quite marked inhibitory effects on the enzyme. The abilities of the compounds synthesized here to inhibit adenosine deaminase were found to depend on their structure. It is of note that virtually all the compounds inhibited the high molecular weight form of the enzyme to a significantly lesser extent than the low molecular weight form.

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Section: Experimental Chemical Sectionmentioning

confidence: 99%

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confidence: 99%

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Synthesis of 2-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]propan-1-ol dihydrochlorides and their effects on adenosine deaminase activity

et al. 2011

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“…The a-phenyl-b-morpholino-4-fluoropropiophenone (II) that was necessary for the aforementioned synthesis was prepared by aminomethylation, the reaction of 4-fluorophenylbenzylketone (I) with paraform and morpholine in EtOH [2,3].…”

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confidence: 99%

“…The reaction of II with various Grignard reagents produced a new series of tertiary aminoalcohols (IIIa -h) as oily compounds that were converted to the crystalline hydrochlorides (IVa -h) in order to study their biological properties [2,4,5].…”

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Synthesis and antioxidant activity of 1-(4-fluorophenyl)-1-alkyl-2-phenyl-3-morpholinopropan-1-ol hydrochlorides

et al. 2011

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Reactions of 4-fluorophenyl-b-morpholinopropiophenones with various Grignard reagents in anhydrous ether produced new tertiary aminoalcohols, 1-(4-fluorophenyl)-1-alkyl-2-phenyl-3-morpholinopropan-1-ols, that can be regarded as trihexyphenidyl (cyclodol) analogs. The antioxidant properties of the synthesized compounds were studied using a photochemiluminescence analytical method. It is established that the synthesized compounds exhibit antioxidant activity, the intensity of which depends on the length of the alkyl chain in the para-position of the benzene ring.

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Visible Light Photoredox-Catalyzed α-Alkylation of Cyclic Tertiary Arylamines

Wang

et al. 2019

J. Org. Chem.

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Cited by 5 publications

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Synthesis of 2-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]propan-1-ol dihydrochlorides and their effects on adenosine deaminase activity

Synthesis of 2-(4-substituted phenyl)-3-[4-substituted piperazino(piperidino)]propan-1-ol dihydrochlorides and their effects on adenosine deaminase activity

Synthesis and antioxidant activity of 1-(4-fluorophenyl)-1-alkyl-2-phenyl-3-morpholinopropan-1-ol hydrochlorides

Visible Light Photoredox-Catalyzed α-Alkylation of Cyclic Tertiary Arylamines

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