Untitled

Brown, Christine; West, Douglas X.

doi:10.1023/a:1022963715764

Cited by 13 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar structural correlation was found before in the IC 50 data obtained for phosphinothiosemicarbazone Au(I) complexes [36]. However, the influence of the ionic/neutral nature of the complexes could not be assessed in this case because of the non-helical nature of the bisthiosemicarbazone complexes containing the neutral ligands with anions acting as ligands or counterions [37].…”

Section: Cytotoxicity Studiessupporting

confidence: 78%

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Fernández-Fariña

Velo-Heleno

Carballido

et al. 2023

IJMS

View full text Add to dashboard Cite

The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bisthiosemicarbazone ligands with different terminal groups, Zn2(LMe)2∙2H2O 1, Zn2(LPh)2∙2H2O 2 and Zn2(LPhNO2)23, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demonstrating in all cases low toxicity and an absence of covalent interaction with the proteins and oligonucleotides. The in vitro cytotoxicity of the helicates was tested against MCF-7 (human breast carcinoma), A2780 (human ovarian carcinoma cells), NCI-H460 (human lung carcinoma cells) and MRC-5 (normal human lung fibroblasts), comparing the IC50 values with cisplatin. We will try to demonstrate if the terminal substituent of the ligand precursor exerts any effect in toxicity or in the antitumor activity of the zinc helicates.

show abstract

Section: Cytotoxicity Studiessupporting

confidence: 78%

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Fernández-Fariña

Velo-Heleno

Carballido

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…The sum of angles about palladium is 359.84°, Pd(1), 360.08°, Pd(2); with the distortions most noticeable in the somewhat reduced "bite" angles of N(1)-Pd(1)-S(1) 82.8 (3), and N(5)-Pd(2)-S(2) 83.9(3), of the the thiosemicarbazone moiety consequent upon chelation. The palladium-nitrogen bond lengths in the metallacycle [2.085(13) Å , Pd(1); 2.069(13) Å , Pd (2)] are longer than the predicted single bond value of 2.011 Å , based on the sum of covalent radii for nitrogen(sp 2 ) and palladium, 0.701 and 1.31 Å , respectively [31], and reflect the trans influence of the phosphorus atom [32,33].…”

Section: Crystal Structure Of [{Pd[c 4 H 4 Nc(h)‫؍‬ Nnc(s)nhme](cl)} mentioning

confidence: 99%

“…Thiosemicarbazones, produced by condensation of a thiosemicarbazide and an aldehyde or ketone, are multiple purpose ligands owing to the display of binding possibilities they offer in coordination chemistry [1,2], which stem from the various donor atoms afforded by the ligands, and from their thione-thiolate tautomeric equilibrium. Furthermore, those with additional donor atoms linked to the carbonylic carbon via an aromatic ring, such as phenoxy oxygen or pyridinic nitrogen, among others, may bind to metal centres in a terdentate mode [3], and there is a great deal of information regarding thiosemicarbazone complexes bearing different metal atoms [4]. Lately, a new approach to thiosemicarbazone compounds has come into existence within the field of organometallic chemistry, namely cyclometallated compounds, which display σ metal-carbon bonds, rendering compounds with terdentate [C, N, S] thiosemicarbazone [5], that show two fused rings at the metal atom.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Pyrrolthiosemicarbazone Complexes of Palladium(II). Crystal Structures of [{Pd[C₄H₄NC(H)=NNC(S)NHMe](Cl)}₂{μ‐Ph₂P(CH₂)₃PPh₂}] and[Pd{C₄H₄NC(H)=NNC(S)NHMe}{Ph₂P(CH₂)₂PPh₂‐P, P}](Cl)

Adrio

Alberdi

Amoedo

et al. 2005

Zeitschrift anorg allge chemie

View full text Add to dashboard Cite

Reaction of the thiosemicarbazone ligands C 4 H 4 NC(H)ϭ NN(H)C(S)NHR (R ϭ Me, a; Et, b) with Li 2 [PdCl 4 ] gave the dinuclear complexes [Pd{C 4 H 4 NC(H)ϭNNC(S)NHR}(μ-Cl)] 2 (R ϭ Me, 1a; Et, 1b) with a central Pd 2 Cl 2 core and with deprotonation of the thiosemicarbazones at the hydrazinic nitrogen atom. Treatment of 1a and 1b with triphenylphosphine gave the mononuclear compounds [Pd{C 4 H 4 C(H)ϭNNC(S)NHR}(Cl)(PPh 3 )] (R ϭ Me, 2a; Et, 2b), whereas reaction of 1a and 1b with tertiary diphosphines gave mono-and dinuclear compounds, as appropriate, with the 2197 corresponding diphosphine acting as a monodentate (6b), chelating (3a) and bridging ligand ( 4a, 5a, 4b, 5b). Treatment of 1a and 1b with (Ph 2 PCH 2 CH 2 PPh 2 )W(CO) 5 gave the new heterobimetallic complexes 7a and 7b. The crystal structures of complexes 3a and 4a are described.

show abstract

“…The infrared spectrum of AllPmTu, measured in a KBr disc, shows two bands at 3207 and 3170 cm )1 , assignable to (N1H) and (N2H), respectively [7,8]. The appearance of two bands for the NH groups of the thiourea part and the absence of a strong band in the 2500-2300 cm )1 region due to m(S-H) [8,9], is evidence for the existence of AllPmTu in the thione form in the solid state. The i.r.…”

Section: Ir Spectramentioning

confidence: 99%

“…This result is supported by the appearance of new bands at ca. 280, 313 and 420 cm )1 , attributable to m(Pt-N) m(Pd-N) and m(Ni-N) [9,[12][13][14][15], respectively. On the other hand, the i.r.…”

Section: Ir Spectramentioning

confidence: 99%

Nickel(II), palladium(II) and platinum(II) complexes of N-allyl-N′-pyrimidin-2-ylthiourea

Kandil

Katib

Yarkandi

2007

Transition Met Chem

View full text Add to dashboard Cite

Platinum(II), palladium(II) and nickel(II) complexes with N-allyl-N¢-pyrimidin-2-ylthiourea were synthesized in 1:1 and 1:2 [metal:ligand] stoichiometric ratios and characterized by elemental analyses, molar conductivities, magnetic susceptibilities and by i.r., u.v.-vis., 1 H-and 13 C-n.m.r. and mass spectra. The 1 H-and 13 C-n.m.r. chemical shifts reveal coordination of one pyrimidine-N and sulphur atoms to Pt II and Pd II . The i.r. spectra indicate that the ligand behaves as a neutral monodentate towards Ni II ; coordinates via a pyrimidine-N and as a bidendate towards Pd II and Pt II coordinates via thione-S and a pyrimidine-N. The magnetic moments and electronic spectral data suggest a square-planar geometry for Pt II and Pd II complexes, a mixture of square-planar and tetrahedral geometries for the tetracoordinate Ni II complex and octahedral for the six-coordinate one. The E.I. mass spectra of the complexes showed some isotope ion peaks of [M] + and fragments containing metals; assignments of fragments containing metal ions were supported by the appearance of their peaks among isotope clusters.

show abstract

Untitled

Cited by 13 publications

References 32 publications

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Synthesis and Characterization of Pyrrolthiosemicarbazone Complexes of Palladium(II). Crystal Structures of [{Pd[C₄H₄NC(H)=NNC(S)NHMe](Cl)}₂{μ‐Ph₂P(CH₂)₃PPh₂}] and[Pd{C₄H₄NC(H)=NNC(S)NHMe}{Ph₂P(CH₂)₂PPh₂‐P, P}](Cl)

Nickel(II), palladium(II) and platinum(II) complexes of N-allyl-N′-pyrimidin-2-ylthiourea

Contact Info

Product

Resources

About

Untitled

Cited by 13 publications

References 32 publications

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Synthesis and Characterization of Pyrrolthiosemicarbazone Complexes of Palladium(II). Crystal Structures of [{Pd[C4H4NC(H)=NNC(S)NHMe](Cl)}2{μ‐Ph2P(CH2)3PPh2}] and[Pd{C4H4NC(H)=NNC(S)NHMe}{Ph2P(CH2)2PPh2‐P, P}](Cl)

Nickel(II), palladium(II) and platinum(II) complexes of N-allyl-N′-pyrimidin-2-ylthiourea

Contact Info

Product

Resources

About

Synthesis and Characterization of Pyrrolthiosemicarbazone Complexes of Palladium(II). Crystal Structures of [{Pd[C₄H₄NC(H)=NNC(S)NHMe](Cl)}₂{μ‐Ph₂P(CH₂)₃PPh₂}] and[Pd{C₄H₄NC(H)=NNC(S)NHMe}{Ph₂P(CH₂)₂PPh₂‐P, P}](Cl)