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Abstract

Dimethyl isosorbide (DMI), which is currently under investigation for its potential use as a pharmaceutical vehicle and drug permeation enhancer, is a water-miscible liquid with relatively low viscosity. The solubilization behavior of DMI as a cosolvent for nonpolar drugs was characterized via dielectric constant measurements of binary solvent systems containing DMI and either water, propylene glycol (PG), or polyethylene glycol (PEG). Evidence from the dielectric constant profiles and NMR studies suggest that DMI undergoes complexation with water and PG, but not with PEG, through hydrogen bonding interactions. The solvent complexation exhibited a major effect on the solubilities of prednisone, dexamethasone, and prednisolone in the mixed solvent systems. Maximum solubility of each drug was found to occur near a DMI/water or DMI/PG concentration ratio of 1:2. In the DMI-PEG mixed system, while there is no apparent interaction between DMI and PEG molecules, the solubility of prednisone was found to increase with decreasing dielectric constant.

A Quantitative MALDI-MSI Study of the Movement of Molecules in Biological Systems

“…DMI acts as chemical enhancer by improving the partitioning of active agents into the stratum corneum and leading to a greater penetration of them into the epidermis (Zia et al, 1991;Otto et al, 2008). It was demonstrated that 24 hours post-treatment terbinafine was localised only in the epidermal layers of the LSE, either when the drug was formulated with acetone/olive oil (80:20) or with a known penetration enhancer 100% DMI.…”