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Palágyi, Zs.; Ferenczy, L.; Vágvölgyi, Csaba

doi:10.1023/a:1016689512718

Cited by 23 publications

(4 citation statements)

References 6 publications

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“…Metabolic engineering of microorganisms to produce higher levels of important molecules is a great possibility to improve public health through biotechnology [133]. The selection of appropriate microorganism is the first step in biotechnological processes, which could be undergone to mutagenesis to improve the strains and subsequently the production of metabolites [134]. …”

Section: Introductionmentioning

confidence: 99%

Biotechnological production of carotenoids by yeasts: an overview

et al. 2014

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Nowadays, carotenoids are valuable molecules in different industries such as chemical, pharmaceutical, poultry, food and cosmetics. These pigments not only can act as vitamin A precursors, but also they have coloring and antioxidant properties, which have attracted the attention of the industries and researchers. The carotenoid production through chemical synthesis or extraction from plants is limited by low yields that results in high production costs. This leads to research of microbial production of carotenoids, as an alternative that has shown better yields than other aforementioned. In addition, the microbial production of carotenoids could be a better option about costs, looking for alternatives like the use of low-cost substrates as agro-industrials wastes. Yeasts have demonstrated to be carotenoid producer showing an important growing capacity in several agro-industrial wastes producing high levels of carotenoids. Agro-industrial wastes provide carbon and nitrogen source necessary, and others elements to carry out the microbial metabolism diminishing the production costs and avoiding pollution from these agro-industrial wastes to the environmental. Herein, we discuss the general and applied concepts regarding yeasts carotenoid production and the factors influencing carotenogenesis using agro-industrial wastes as low-cost substrates.

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Section: Introductionmentioning

confidence: 99%

Biotechnological production of carotenoids by yeasts: an overview

et al. 2014

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“…Generally, X. dendrorhous shows a broad substrate spectrum. 30 Accordingly, a total of 15 carbon sources including arabinose, cellobiose, ethanol, formic acid, fructose, galactose, glucose, glycerol, lactose, mannose, methanol, starch, maltose, sucrose, and xylan, were chosen to investigate their effects on the microbial growth and astaxanthin production by strain DW6 in shake flasks. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1C, the astaxanthin was mainly synthesized via the mevalonate pathway (MVA), which starts with the condensation of acetyl-CoA to isopentenyl pyrophosphate (IPP), the precursor for astaxanthin synthesis. 30 The IPP can be converted into dimethylallyl pyrophosphate (DMAPP) by IPP isomerase, and then the IPP and DMAPP molecules can be condensed to geranyl pyrophosphate (GPP) under the catalysis of GPP synthase. The GPP can be further condensed to geranylgeranyl pyrophosphate (GGPP) by GGPP synthase.…”

Section: Isolation and Draft Genome Sequence Analysis Of The Newly Is...mentioning

confidence: 99%

High astaxanthin production by Xanthophyllomyces dendrorhous strain DW6 from cane molasses using two-stage pH strategies

Zhou,

Yang,

Guo

et al. 2024

Green Chem.

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“…The commercial scale biological production of astaxanthin is accomplished through cultivation of the green algae Haematococcus pluvalis or the red yeast P. rhodozyma [6]. Due to its ability to utilize all of the major sugars that can be generated from biomass (i.e., glucose, xylose, and arabinose), P. rhodozyma is of particular interest in biomass applications [7]. Unfortunately, astaxanthin levels achieved by wild-type strains of the organism often are too low to be economically feasible.…”

Section: Introductionmentioning

confidence: 99%

Production of Astaxanthin from Cellulosic Biomass Sugars by Mutants of the Yeast Phaffia rhodozyma

Montanti

Nghiem

Johnston

2011

Appl Biochem Biotechnol

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Astaxanthin is a potential high-value coproduct in an ethanol biorefinery. Three mutant strains of the astaxanthin-producing yeast Phaffia rhodozyma, which were derived from the parent strain ATCC 24202 (UCD 67-210) and designated JTM166, JTM185, and SSM19, were tested for their capability of utilizing the major sugars that can be generated from cellulosic biomass, including glucose, xylose, and arabinose, for astaxanthin production. While all three strains were capable of metabolizing these sugars, individually and in mixtures, JTM185 demonstrated the greatest sugar utilization and astaxanthin production. Astaxanthin yield by this strain (milligrams astaxanthin per gram of sugar consumed) was highest for xylose, followed by arabinose and then glucose. The kinetics of sugar utilization by strain JTM185 was studied in fermenters using mixtures of glucose, xylose, and arabinose at varied concentrations. It was found that glucose was utilized preferentially, followed by xylose, and lastly, arabinose. Astaxanthin yield was significantly affected by sugar concentrations. Highest yields were observed with sugar mixtures containing the highest concentrations of xylose and arabinose. Hydrolysates produced from sugarcane bagasse and barley straw pretreated by the soaking in aqueous ammonia method and hydrolyzed with the commercial cellulase preparation, Accellerase™ 1000, were used for astaxanthin production by the mutant strain JTM185. The organism was capable of metabolizing all of the sugars present in the hydrolysates from both biomass sources and produced similar amounts of astaxanthin from both hydrolysates, although these amounts were lower when compared to yields obtained with reagent grade sugars.

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Cited by 23 publications

References 6 publications

Biotechnological production of carotenoids by yeasts: an overview

Biotechnological production of carotenoids by yeasts: an overview

High astaxanthin production by Xanthophyllomyces dendrorhous strain DW6 from cane molasses using two-stage pH strategies

Production of Astaxanthin from Cellulosic Biomass Sugars by Mutants of the Yeast Phaffia rhodozyma

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