Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission

Clinical features and outcomes of patients with drug-induced autoimmune hepatitis: A retrospective cohort study

“…In particular, all our patients had a better prognosis and a more complete response to therapy than typical idiopathic AIH patients, in whom, even if there is an initial normalization of LFTs, relapse after withdrawal of immunosuppression is almost the rule [24,25].…”

Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis

“…We believe that treatment withdrawal should be offered to patients with complete biochemical remission (normal transaminases and normal immunoglobulin G) for >2 years under immunosuppressive monotherapy with azathioprine, 11 keeping in mind that in most patients, AIH will require lifelong treatment. 12 Alternative medical treatment is available due to promising results of, for example, mycophenolatemofetil, which was shown to be an effective first-line therapy in an uncontrolled trial. 10 However, mycophenolatemofetil has known severe side effects, such as teratogenicity.…”

Incidence and Characteristics of Autoimmune Hepatitis

“…[15][16][17] Ethnic background has been reported as a key factor in clinical presentation and outcomes for patients with AIH 18,19 ; however, this finding is not universal. 20 In the present national study, our primary aim was to determine the incidence of AIH in children and adolescents in Canada and to describe its clinical characteristics and natural history. In addition, we attempted to identify risk factors for poor outcomes.…”