Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-breast-cancer Agent, Synthesis and In Vitro Evaluations

Amanlou, Massoud; Heidari, Zahra; Siadat, Seyed Davar; Aghasadeghi, Mohammad Reza; Ghorbani, Masoud; Ebrahimi, Seyed Esmaeil Sadat; Sadat, Seyed Mehdi; Hajmohammadi, Mehdi; Arabzadeh, Ali Jabbari; Hekmat, Soheila; Alaei-Beirami, Mahmood; Saraji, Alireza Azizi; Moghaddam, Hadi Fathi; Alavidjeh, Mohammad Shafiee; Delbaz, Seyed Ali; Dashtbani-Roozbehani, Abolfazl; Ardestani, Mehdi Shafiee

doi:10.2174/1573406411309040006

Cited by 3 publications

(1 citation statement)

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“…23 Other than the GLUT family, the expression of sodium-dependent glucose transporters (SGLT1 and SGLT2) was also found to be related to cancer survival in pancreatic adenacarcinoma 24 and metastasis of lung cancer. 25 Glucose-conjugated anticancer drugs have been shown to target tumor tissue based on increased glucose uptake in cancer cells: glufosfamide, 26 paclitaxel, 27 doxorubicin, 28 and tamoxifen 29 glycoconjugates were synthesized and tested for cancer targeting, and glucose conjugation was found to enhance the solubility and cellular uptake of these drugs. Many clinical trials also utilized glycoconjugates for targeting tumors and decreasing side effects of chemotherapeutics.…”

Section: ■ Introductionmentioning

confidence: 99%

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Mumcuoglu

Ekiz

Günay

et al. 2016

ACS Appl. Mater. Interfaces

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Oligonucleotides are promising drug candidates due to the exceptionally high specificity they exhibit toward their target DNA and RNA sequences. However, their poor pharmacokinetic and pharmacodynamic properties, in conjunction with problems associated with their internalization by cells, necessitates their delivery through specialized carrier systems for efficient therapy. Here, we investigate the effects of carrier morphology on the cellular internalization mechanisms of oligonucleotides by using self-assembled fibrous or spherical peptide nanostructures. Size and geometry were both found to be important parameters for the oligonucleotide internalization process; direct penetration was determined to be the major mechanism for the internalization of nanosphere carriers, whereas nanofibers were internalized by clathrin- and dynamin-dependent endocytosis pathways. We further showed that glucose conjugation to carrier nanosystems improved cellular internalization in cancer cells due to the enhanced glucose metabolism associated with oncogenesis, and the internalization of the glucose-conjugated peptide/oligonucleotide complexes was found to be dependent on glucose transporters present on the surface of the cell membrane.

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Section: ■ Introductionmentioning

confidence: 99%

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Mumcuoglu

Ekiz

Günay

et al. 2016

ACS Appl. Mater. Interfaces

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Drug conjugates—an emerging approach to treat breast cancer

Hasan

Leak

Stratford

et al. 2018

Pharmacology Res & Perspec

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Breast cancer treatment using a single drug is associated with a high failure rate due, in part, to the heterogeneity of drug response within individuals, nonspecific target action, drug toxicity, and/or development of resistance. Use of dual‐drug therapies, including drug conjugates, may help overcome some of these roadblocks by more selective targeting of the cancer cell and by acting at multiple drug targets rather than one. Drug‐conjugate approaches include linking drugs to antibodies (antibody‐drug conjugates), radionuclides (radioimmunoconjugates), nanoparticles (nanoparticle‐drug conjugates), or to other drugs (drug‐drug conjugates). Although all of these conjugates might be designed as effective treatments against breast cancer, the focus of this review will be on drug‐drug conjugates because of the increase in versatility of these types of drugs with respect to mode of action at the level of the cancer cell either by creating a novel pharmacophore or by increasing the potency and/or efficacy of the drugs’ effects at their respective molecular targets. The development, synthesis, and pharmacological characteristics of drug‐drug conjugates will be discussed in the context of breast cancer with the hope of enhancing drug efficacy and reducing toxicities to improve patient quality of life.

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Drug Delivery Applications of Peptide Materials

Hamsici

Günay

Kirit

et al. 2020

Peptide-Based Biomaterials

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Peptides play an essential role in biotechnological applications as therapeutic and diagnostic agents due to their tunable activity for desired function. So far, a variety of peptide therapeutics and their peptide-based carriers have been engineered for drug delivery applications. However, in order to design and develop such systems for tissue-specific applications, the cellular microenvironment must be properly considered. Peptide-based materials have vast potential applications, particularly for cancer-related systems. Thus, in this chapter, we first focus on different design strategies and considerations for drug-release mechanisms in peptide-based materials. Then, we explain how tumor microenvironments may be distinguished from healthy tissue, including discussion of tumor-specific drug delivery strategies. Finally, the growing significance of peptide chemotherapeutics will be emphasized in terms of design concerns and current applications.

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Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-breast-cancer Agent, Synthesis and In Vitro Evaluations

Cited by 3 publications

References 0 publications

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Cellular Internalization of Therapeutic Oligonucleotides by Peptide Amphiphile Nanofibers and Nanospheres

Drug conjugates—an emerging approach to treat breast cancer

Drug Delivery Applications of Peptide Materials

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