“…Forty-two 6-week-old male F344/DuCrj rats (Charles River Laboratories Japan, Hino, Shiga, Japan) were injected intraperitoneally with a single dose (6 mg/kg body weight) of CDDP (Nippon Kayaku Co. Ltd., Tokyo, Japan) 13 . They were housed in an animal room controlled at 22 ± 3°C with a 12 hour light-dark cycle and allowed free access to a standard commercial diet (MF, Oriental Yeast Co. Ltd., Tokyo, Japan) and tap water.…”