Presence of High-Risk Human Papillomavirus Genotype and Human Immunodeficiency Virus DNA in Anal High-Grade and Low-Grade Squamous Intraepithelial Lesions

Abstract

Human immunodeficiency virus type 1 (HIV)-infected individuals are at risk for anal cancer, which is caused by human papillomavirus (HPV). The relationship between HIV and HPV that leads to anal cancer remains unclear. Recent data, however, suggest that the continued persistence of HIV DNA in patients treated with combined antiretroviral therapy leads to progression of HIV disease and other HIV-associated complications. Therefore, we investigated the relationship among anal low-and high-grade squamous intraepithelial lesions (LGSIL/ HGSIL), high-risk HPV genotypes, and high HIV DNA copy numbers. Anal cytology specimens were assayed for HPV genotype and HIV DNA copy number. High-risk HPV genotypes (odds ratio OR: 3.73; 95% confidence interval CI: 1.08-12.91; p = 0.04) and high HIV DNA copy numbers (OR per 100 HIV DNA copies : 1.13; 95% CI: 1.01-1.27, p = 0.04) were both associated with LGSIL/HGSIL. When considering both high-risk HPV genotypes and HIV DNA copy numbers in predicting LGSIL/HGSIL, HIV DNA copy number was significant (OR per 100 HIV DNA copies : 1.09; 95% CI: 0.96-1.23, p = 0.04) but not high-risk HPV genotypes (OR: 2.30, p = 0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis.

HIV and Other Sexual Transmitted Infections—Challenges for Liberal Prevention Strategies

“…Regarding the HPV there is growing concern for MSM [65]. This is not just pertaining to the "increased risk" of acquiring HIV if already infected by HPV [66] and vice versa [67], but also due to "anal intraepithelial neoplasia cases" [68]- [70] , and HPV-associated oropharyngeal squamous cell carcinoma (SCC), in particular pertaining to MSM and other people practicing oral sex activities [71]. A vaccination is available to prevent infection of the most serious HPV genotypes 16 and 18.…”