228. Polycyclic aromatic hydrocarbons. Part XXXVI. Synthesis of the metabolic oxidation products of 3 : 4-benzpyrene

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

“…This interest is manifested by numerous metabolic studies of BP both in vivo (3)(4)(5)(6)(7)(8)(9) and in vitro (10)(11)(12)(13)(14)(15)(16)(17), the testing of BP and its metabolites for their carcinogenic and mutagenic potency (18,19), and binding studies of BP and its metabolites to nucleic acids and polynucleotides (15,(20)(21)(22)(23). The growing evidence that arene oxides are ultimate carcinogens of polycyclic aromatic hydrocarbons (24,25), and the established intermediacy of arene oxides in the metabolism of several of these hydrocarbons (26)(27)(28)(29), make a critical examination of the metabolism of BP imperative.…”

Syntheses of selected .epsilon.-(2- or 9-anthryl)alkanoic acids and certain esters - carbon-13 spin-lattice relaxation time measurements of methyl 5-(2-anthryl)pentanoate and methyl 7-(2-anthryl)heptanoate

“…The Pyridine Group. For pyridine, and indeed generally for the amine class, the traditionally recommended siccatives are the alkali and alkali earth hydroxides and oxides.11 Thus, literature prescriptions commonly advocate distillation from KOH,12a-b standing over BaO,12c or distillation from CaH2,13 the employment of the latter procedure reportedly yielding samples containing [18][19][20] ppm of residual water. The use of A1203 has also been occasionally reported.14 Our results for pyridine obtained by application of the radiotracer technique are summarized in Table I.…”

Pioneers of Carbon‐rich Compounds

“…Cook, another key personality of the decade, began delineation of his work on carbon-rich systems in two published journal series, Polycyclic Aromatic Hydrocarbons [31] and Production of Cancer by Pure Hydrocarbons, [32] in the early 1930s. The motivation for the research was the structural basis for cancer-causing compounds and his methodology consisted of administering vapor and in vivo doses to laboratory rats.…”