Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non–Small-Cell Lung Cancer Risk in Chinese Nonsmokers

Association between interleukin-4 polymorphisms and environment and nonsmall cell lung cancer in Chinese population

“…Our results are not in agreement with those of the study by Gomes et al [9] These differences may primarily be attributed to the distinct genetic background and the different living environments of the Chinese population compared with other populations. [4,13] Together with earlier studies, [4,[13][14][15] our date suggested that environmental agents might have the potential for interacting with human genetic polymorphisms in NSCLC.…”

“…[3] Recent studies have provided evidence that gene polymorphisms may influence the susceptibility to NSCLC. [4,5] Interleukin-4 (IL-4) is a major role in some carcinomas (oral, [6] gastric, [7] renal, [8] lung [9] ), which plays an important role in regulating the immune response of B-cells, T-cells, and macrophages against infections and malignant cells. [6,10] The human IL-4 gene is located within the cytokine gene cluster on chromosome 5q31 1, [11,12] where an important polymorphism − 590C/T polymorphism (rs2243250) in the promoter region has been identified.…”

Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

“…SCC is more often attributed to cigarette smoking (Kalemkerian et al, 2013), whereas ADC is more weakly associated with smoking than SCC (Sobue et al, 2002). Besides, genetic study indicated that SCC risk is closely linked to MTH1 gene (Kohno et al, 2006), while ADC risk is significantly associated with TERT, COMT, CYP1A1 and HLA-DQA1 genotypes (Kohno et al, 2010;Ji et al, 2012;Zhang et al, 2013). Several studies have investigated the association of the GSTM1 genotype with histologic subtypes of LC (To-Figueras et al, 1997;Stucker et al, 2002;Nazar-Stewart et al, 2003;Alexandrie et al, 2004;Schneider et al, 2004;Sobti et al, 2008).…”

Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population

“…Most NSCLC cases are diagnosed at advanced stages of the disease, leading to poor five-year survival rate (16% overall survival rate) [2]. In previous studies, we demonstrated that NSCLC risk is present in different ethnic groups [3][4][5][6][7][8]. These data indicate that genetic susceptibility is the most important factor in lung cancer development and contributes to individual lung cancer risk.…”