225 Focal Salvage Therapy Compared to Whole-Gland Salvage: A Feasibility Study

Ahmed, Hashim U.; Cathcart, Paul; McCartan, Neil; Kirkham, Alex; Allen, Casey L.; Freeman, A.; Emberton, Mark

doi:10.1016/s1569-9056(11)60225-x

Cited by 2 publications

(1 citation statement)

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“…For recurrence on the treated side, surgery, cryotherapy or HIFU can be considered. However, whole gland salvage HIFU for brachytherapy failures has been associated with a recto‐urethral fistula rate of 60% (3/5 patients) [52], and about 2% for whole gland salvage for failed external beam radiotherapy; the rate for focal HIFU after failed external beam radiotherapy is 2.5% [53,54]. Limited data exist on salvage cryotherapy for brachytherapy failure with the absence of prospective clinical trials (although it is likely that similar rates of rectal toxicity are probable).…”

Section: Consensus Findingsmentioning

confidence: 99%

Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer

et al. 2012

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What's known on the subject? and What does the study add? Whole gland brachytherapy has been used to successfully treat prostate cancer but the protocol for focal therapy has not previously been established. The consensus findings provide guidance on patient selection for focal brachytherapy as well as recommendations for conducting therapy and patient follow‐up. Low dose rate prostate brachytherapy is an effective treatment for localized prostate cancer. Recently, it has been considered for use in a focused manner whereby treatment is targeted only to areas of prostate cancer. The objective of focal brachytherapy is to provide effective cancer control for low‐risk disease but with reduced genitourinary and rectal side‐effects in a cost‐effective way. We report on the outputs of a consensus meeting of international experts in brachytherapy and focal therapy convened to consider the feasibility and potential development of focal brachytherapy. A number of factors were considered for focal brachytherapy including optimal patient selection, disease characterization and localization, treatment protocols and outcome measures. The consensus meeting also addressed the design of a clinical trial that would assess the oncological outcomes and side‐effect profiles resulting from focal brachytherapy.

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Section: Consensus Findingsmentioning

confidence: 99%