223: C-reactive protein (CRP) may predict transplant-related mortality after allogeneic hematopoietic cell transplant (HCT)

Artz, Andrew S.; Wickrema, Amittha; Stock, Wendy; Daugherty, C. K.; Godley, Lucy A.; Kocherginsky, Masha; Odenike, O.; Pollyea, Daniel A.; Rich, Elizabeth Shima; Ulsazek, J.; Larson, Robin J.; Besien, Koen van

doi:10.1016/j.bbmt.2006.12.228

Cited by 3 publications

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“…14-16 Low levels of serum albumin have been shown in previous studies to correlate with regimen-related toxicity and predict higher transplant-related mortality. 3, 17 The correlation between low albumin and mesenteric edema in our study may be explained by one or both of the following mechanisms: ( i ) direct effect of low albumin causing fluid extravasation, ( ii ) intestinal barrier damage causing both mesenteric inflammation/edema and protein enteropathy resulting in albumin loss. Also, albumin is a “negative acute-phase protein”, thus low albumin levels may reflect the acute inflammation (i.e.…”

Section: To the Editormentioning

confidence: 71%

Early post-transplant contrast-enhanced abdominopelvic CT scan predicts the risk of subsequent acute GvHD

Rashidi

Lin

Cashen

2015

Bone Marrow Transplant

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Section: To the Editormentioning

confidence: 71%

Early post-transplant contrast-enhanced abdominopelvic CT scan predicts the risk of subsequent acute GvHD

Rashidi

Lin

Cashen

2015

Bone Marrow Transplant

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“…In some studies serum albumin level was used to eliminate the ferritin elevation as an acute phase reactant. 4,10,15,32 There is a possibility that the adverse prognostic impact of pre-HSCT hyperferritinemia may be related to factors independent of iron overload. 12,31 The laboratory sign of iron overload is ferritin elevation in the presence of increased transferrin saturation.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

Malkan¹

2016

UHOD

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The impacts of serum iron parameters and/or radiological evidence of systemic iron overload on the prognosis of hematopoietic stem cell transplantation (HSCT) in acute leukemia are controversial. Unfortunately, some of the studies evaluating iron overload in transplant setting did not precisely show the patients with iron overload, mainly due to ignoring consideration of transferrin saturation along with hyperferritinemia for elimination of non-iron overload etiologies of hyperferritinemia. The aim of this study is to assess the effect of iron overload on transplantation related complications and prognosis in acute leukemia. Patients who undergone allogeneic HSCT for acute leukemia in Hacettepe University Medical School Department of Hematology were screened retrospectively in order to find cases with serum iron tests within 9 months before transplant. The endpoints investigated were overall and disease-free survivals, acute and chronic graft-versus-host disease and veno-oclussive disease (VOD). There were 84 patients suitable for inclusion. When various ferritin plus transferrin saturation (TS) cut-off values were investigated for a possible relationship with major transplant-related complications/results only ferritin> 2000 plus TS> 45% was found to have an association with VOD at borderline significance (p= 0.067). In conclusion, we observed a non-significant borderline relationship between iron overload and post-transplant VOD. We did not confirm other post-transplant complications reported in the literature. It must be noticed that although many studies intended to investigate the relationship between iron status and transplant outcomes, only a few of them have really looked for the effect of iron overload. Keywords: Iron overload, Acute leukemia, Transplantation ÖZET Akut Löseminin Prognozu ve Transplantasyonla İlişkili Komplikasyonlarına Demir Yükselmesinin EtkisiSerum demir parametrelerinin ve/veya radyolojik olarak saptanan sistemik demir yüklenmesinin, kök hücre nakli (KHN) yapılmış akut lösemi hastalarının prognozuna olan etkisi tartışmalıdır. Ne yazık ki, demir yüklenmesinin transplantasyona olan etkisini araştıran bazı çalışmalarda demir yüklenmesi olan hastalar doğru bir şekilde saptanamamıştır. Bunun nedeni hiperferritineminin demir yüklenmesi dışındaki sebeplerinin göz ardı edilmesidir. Bu çalışmanın amacı, demir yüklenmesinin akut lösemi hastalarının prognozuna ve transplantasyon ile ilişkili komplikasyonlarına olan etkisinin araştırılmasıdır. Transplantasyon öncesi dokuzuncu aya kadar olan serum demir testleri olan hastaları bulmak amacıyla, Hacettepe Üniversitesi Tıp Fakültesi Hematoloji Departmanı'nda allojenik KHN yapılan hastalar retrospektif olarak taranmıştır. Çalışma sonlanım noktaları, genel ve hastalıksız sağkalım süreleri, akut ve kronik graft versus host hastalığı ve venookluziv hastalıktır (VOH). Çalışmaya alınma kriterlerine uyan 84 hasta mevcuttu. Transplant ilişkili komplikasyonlar ile demir yüklenmesi arasında bir ilişki bulabilmek amacı ile transferrin satürasyonu (TS) ...

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“…For example, we found a combination of high comorbidity (ie, HCT-CI scores of 3 or more) and functional impairment by IADL produced a simple 3-level scoring system with appreciable discrimination: 2-year survival rates exceeded 60% for no risk factors compared with 29% and 0% for those with 1 or 2 risk factors in patients 60 years and older, respectively. Biomarkers such as elevated C-reactive protein and depressed albumin add prognostication discrimination to comorbidity and age [72,86]. Hypoalbuminemia (<3.5 g/dL) can be applied as a readily available biomarker in light of the established and independent risks of NRM.…”

Section: Other Health Domainsmentioning

confidence: 99%

Reprint of: Aging: Treating the Older Patient

Rosko

Artz

2017

Biology of Blood and Marrow Transplantation

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223: C-reactive protein (CRP) may predict transplant-related mortality after allogeneic hematopoietic cell transplant (HCT)

Cited by 3 publications

References 0 publications

Early post-transplant contrast-enhanced abdominopelvic CT scan predicts the risk of subsequent acute GvHD

Early post-transplant contrast-enhanced abdominopelvic CT scan predicts the risk of subsequent acute GvHD

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

Reprint of: Aging: Treating the Older Patient

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