Carotid plaque is associated with increased cardiac mortality in patients with coronary artery disease

Park, Hyun Woong; Kim, Wan Ho; Kim, Ki Hong; Yang, Donghwa; Kim, Ji Hye; Song, In Geol; Kwon, Taek Geun; Bae, Jang–Ho

doi:10.1016/j.ijcard.2011.11.084

Cited by 37 publications

(43 citation statements)

References 22 publications

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“…[1][2][3][4] The largest of these studies was an analysis from the international Reduction of Atherothrombosis for Continued Health (REACH) registry. 1 At the time of enrollment, ≈23 000 registry patients had evidence of CA (defined as any degree of carotid plaque regardless of luminal stenosis, evidenced either by a history of carotid revascularization or by a physician report documenting ≥1 carotid plaque or a carotid stenosis ≥70%).…”

Section: Previous Studiesmentioning

confidence: 99%

“…[1][2][3][4] In fact, progressive carotid artery stenosis (CAS) is reportedly a stronger predictor of imminent myocardial infarction (MI) than of future stroke events. 5 Previous outcome studies relating the presence of atherosclerotic carotid artery lesions to the risk of future coronary events have varied methodologically in the definition of carotid atherosclerosis (CA) and CAD.…”

mentioning

confidence: 99%

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Impact of Carotid Atherosclerosis on the Risk of Adverse Cardiac Events in Patients With and Without Coronary Disease

Steinvil

Sadeh

Bornstein

et al. 2014

Stroke

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Consecutive hospitalized and ambulatory patients undergoing nonemergent coronary angiography between January 2007 and May 2009 were enrolled in the Tel-Aviv Prospective Angiography Study, as previously described. 8 Patients undergoing a carotid ultrasoundBackground and Purpose-Carotid atherosclerosis (CA) is reportedly a strong predictor of imminent cardiac events even in the absence of established coronary artery disease (CAD). We examined the differential impact of CA on the risk of major adverse cardiovascular events in patients with and without CAD diagnosed angiographically. Methods-We conducted a follow-up survey of 1391 patients who underwent clinically driven coronary angiography and a same-day carotid ultrasound and Doppler study. Definitions of CAD, CA, and carotid artery stenosis were in accordance with current practice guidelines.

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Section: Previous Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

Impact of Carotid Atherosclerosis on the Risk of Adverse Cardiac Events in Patients With and Without Coronary Disease

Steinvil

Sadeh

Bornstein

et al. 2014

Stroke

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“…Increased cardiovascular mortality is related to traditional (low physical activity, smoking, diabetes, arterial hypertension, obesity, dyslipidaemia) as well as non-traditional risk factors, such as: chronic kidney disease, anaemia, chronic microinflammation, elevated levels of homocysteine and total bilirubin, and intima-media thickness (IMT) of the carotid artery (Babińska et al, 2005;Gul et al, 2013;Park et al, 2013;Shroff et. al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Limitations of Cox Proportional Hazards Analysis in Mortality Prediction of Patients with Acute Coronary Syndrome

Babińska

Chudek

Chełmecka

et al. 2015

Studies in Logic, Grammar and Rhetoric

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Abstract. The aim of this study was to evaluate the possibility of incorrect assessment of mortality risk factors in a group of patients affected by acute coronary syndrome, due to the lack of hazard proportionality in the Cox regression model. One hundred and fifty consecutive patients with acute coronary syndrome (ACS) and no age limit were enrolled. Univariable and multivariable Cox proportional hazard analyses were performed. The proportional hazard assumptions were verified using Schoenfeld residuals, χ2 test and rank correlation coefficient t between residuals and time. In the total group of 150 patients, 33 (22.0%) deaths from any cause were registered in the follow-up time period of 64 months. The non-survivors were significantly older and had increased prevalence of diabetes and erythrocyturia, longer history of coronary artery disease, higher concentrations of serum creatinine, cystatin C, uric acid, glucose, C-reactive protein (CRP), homocysteine and B-type natriuretic peptide (NT-proBNP), and lower concentrations of serum sodium. No significant differences in echocardiography parameters were observed between groups. The following factors were risk of death factors and fulfilled the proportional hazard assumption in the univariable model: smoking, occurrence of diabetes and anaemia, duration of coronary artery disease, and abnormal serum concentrations of uric acid, sodium, homocysteine, cystatin C and NT-proBNP, while in the multivariable model, the risk of death factors were: smoking and elevated concentrations of homocysteine and NT-proBNP. The study has demonstrated that violation of the proportional hazard assumption in the Cox regression model may lead to creating a false model that does not include only time-independent predictive factors.

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“…Carotid plaque is reported as another predictable factor to evaluate the risk of CAD, but not still discovered whether there is any strong association with cardiovascular events in patients with CAD (11). …”

Section: Introductionmentioning

confidence: 99%

Stenosis Level, Plaque Morphology and Intima-Media Thickness of Internal Carotid Artery in Chronic Stable Angina and Acute Coronary Syndrome; A Comparative Study

Valizadeh¹,

Zareie²,

Manafi³

et al. 2015

Iran Red Crescent Med J

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Background:Ischemic heart disease (IHD) is the most common cause of cardiovascular diseases and divided into two main categories as acute coronary syndrome (ACS) and chronic stable angina (CSA). These two groups have stenosis and atherosclerosis in the coronary artery, but are more severe in patients with ACS.Objectives:We aimed to find the association between coroner and internal carotid artery, also comparing prospectively stenosis level, plaque morphology and intima-media thickness of internal carotid between patients with acute coronary syndrome (ACS) and chronic stable angina.Patients and Methods:In this study, 60 patients were enrolled as ACS group chosen from those admitted in CCU or referred to clinic. Forty-five patients of CSA group were chosen from those referred to clinic. All 105 patients underwent color Doppler sonography, and stenosis, plaque morphology and intima media thickness (IMT) were measured.Results:In 60 patients with ACS, 49 (81.7%) had no stenosis in ultrasonography and 11 (18.3%) had some degrees of stenosis; also 28 (46.7%) and 16 (26.7%) of patients had plaque and IMT, respectively. In the rest 45 patients of CSA group, just 4 (8.9%), 17 (37.8%) and 8 (17.8%) patients had stenosis, plaque and IMT, respectively. Therefore, there was no statistically significant difference between the two groups regarding stenosis (P = 0.171), plaque morphology (P = 0.362) and IMT (P = 0.283) (Power = 90%).Conclusions:According to the results, there were no significant and meaningful differences comparing ACS and CSA groups of patients by ECDS using three indicators of stenosis, plaque morphology and IMT as indicators of atherosclerosis. Results also display that patients with ACS had more stenosis, more plaque and thicker intima–media, but these differences were not statistically significant (P < 0.05).

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Carotid plaque is associated with increased cardiac mortality in patients with coronary artery disease

Cited by 37 publications

References 22 publications

Impact of Carotid Atherosclerosis on the Risk of Adverse Cardiac Events in Patients With and Without Coronary Disease

Impact of Carotid Atherosclerosis on the Risk of Adverse Cardiac Events in Patients With and Without Coronary Disease

Limitations of Cox Proportional Hazards Analysis in Mortality Prediction of Patients with Acute Coronary Syndrome

Stenosis Level, Plaque Morphology and Intima-Media Thickness of Internal Carotid Artery in Chronic Stable Angina and Acute Coronary Syndrome; A Comparative Study

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