Abstract:Age and logistic Euroscore might be inadequate criteria for the identification of patients with severe aortic stenosis unsuitable for AVR and addressable to TAVI.
“…1, middle box). Nevertheless, there is an ongoing discussion on whether risk stratification is appropriate and sufficient in allocating patients to TAVI instead of (surgical) AVR [10][11][12][13].The differences in combinations of risk factors present in high-risk patients (Table 1), as well as subgroup analyses of TAVI outcomes and sensitivity analyses in economic evaluations of TAVI age [17,18,29], suggest that benefits and risks, as well as costs, may vary substantially between subgroups within the high-risk category. This indicates that providing either all or none of the high-risk patients with TAVI is both unlikely to be optimal.…”
Section: Discussionmentioning
confidence: 99%
“…Next, we performed cluster analysis to identify subgroups among patients within the high-risk category. As age is oftentimes an important factor in both effectiveness and occurrence of complications of treatment [13], we identified subgroups separately among high-risk patients younger than 75 years of age, and patients aged 75 or older.…”
Section: Identifying Subgroups Among High-risk Cardiac Surgery Patientsmentioning
confidence: 99%
“…1, middle box). [7][8][9], there is an ongoing discussion on whether this is appropriate and sufficient in allocating patients to TAVI instead of (surgical) AVR [10][11][12][13]. Patients would ideally be selected for TAVI or SAVR after discussion by a multidisciplinary heart team [14,15].…”
We illustrated a feasible method to identify homogeneous subgroups of individuals typically comprising risk categories. This allows a single treatment strategy--optimal only on average, across all individuals in a risk category--to be replaced by subgroup-specific treatment strategies, bringing us another step closer to individualized care. Discussions on allocation of cardiac surgery patients to different interventions may benefit from focusing on such specific subgroups.
“…1, middle box). Nevertheless, there is an ongoing discussion on whether risk stratification is appropriate and sufficient in allocating patients to TAVI instead of (surgical) AVR [10][11][12][13].The differences in combinations of risk factors present in high-risk patients (Table 1), as well as subgroup analyses of TAVI outcomes and sensitivity analyses in economic evaluations of TAVI age [17,18,29], suggest that benefits and risks, as well as costs, may vary substantially between subgroups within the high-risk category. This indicates that providing either all or none of the high-risk patients with TAVI is both unlikely to be optimal.…”
Section: Discussionmentioning
confidence: 99%
“…Next, we performed cluster analysis to identify subgroups among patients within the high-risk category. As age is oftentimes an important factor in both effectiveness and occurrence of complications of treatment [13], we identified subgroups separately among high-risk patients younger than 75 years of age, and patients aged 75 or older.…”
Section: Identifying Subgroups Among High-risk Cardiac Surgery Patientsmentioning
confidence: 99%
“…1, middle box). [7][8][9], there is an ongoing discussion on whether this is appropriate and sufficient in allocating patients to TAVI instead of (surgical) AVR [10][11][12][13]. Patients would ideally be selected for TAVI or SAVR after discussion by a multidisciplinary heart team [14,15].…”
We illustrated a feasible method to identify homogeneous subgroups of individuals typically comprising risk categories. This allows a single treatment strategy--optimal only on average, across all individuals in a risk category--to be replaced by subgroup-specific treatment strategies, bringing us another step closer to individualized care. Discussions on allocation of cardiac surgery patients to different interventions may benefit from focusing on such specific subgroups.
PPM after AVR does not affect survival, functional status, and QoL in patients aged at least 75 years. Surgical procedures, often time-consuming, contemplated to prevent PPM, may therefore be not justified in this patient subgroup.
In TAVI patients, ACEF score, STS score and Logistic Euroscore provided only a moderate correlation and a low accuracy both for 30-day and medium-term outcomes. Dedicated scores are needed to properly tailor time and kind of approach.
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