Glaucoma Diagnostic Performance of GDxVCC and Spectralis OCT on Eyes With Atypical Retardation Pattern

Hoesl, L. M.; Tornow, Ralf P.; Schrems, W.; Horn, Folkert K.; Mardin, Christian Y.; Kruse, Friedrich E.; Juenemann, Anselm; Laemmer, Robert

doi:10.1097/ijg.0b013e318237c8c5

Cited by 11 publications

(5 citation statements)

References 26 publications

(14 reference statements)

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“…For this study we used the global RNFL thickness, which corresponds to the average RNFL thickness in the 3.4 mm diameter peripapillary circle around the optic nerve head. This parameter has been shown to perform well in the assessment of rates of change in previous studies 17, 20 .…”

Section: Methodsmentioning

confidence: 69%

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods

Liu¹,

Tatham²,

Gracitelli³

et al. 2015

Ophthalmology

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Purpose To determine whether progressive retinal nerve fiber layer (RNFL) loss occurs in the contralateral eye of patients with glaucoma showing unilateral progression according to conventional diagnostic methods. Design Prospective longitudinal observational cohort study. Participants 346 eyes of 173 patients (118 eyes with glaucoma and 228 eyes with suspect glaucoma at baseline) recruited from the Diagnostic Innovations Glaucoma Study (DIGS) and followed for an average of 3.5 ± 0.7 years. Methods All subjects had standard automated perimetry (SAP, HFA) and spectral domain optical coherence tomography (SDOCT, Spectralis) in both eyes at 6-month intervals, with a minimum of 5 SAP and 5 SDOCT examinations in each eye. Eyes were determined as progressing by conventional methods if there was progression on masked grading of optic disc stereophotographs or SAP guided progression analysis (GPA, “likely progression”). Rates of change in SDOCT average RNFL thickness were obtained by linear mixed effects model. Rate of global loss was calculated using a random coefficient model and compared for non-progressing patients, progressing eyes and fellow eyes of unilateral progressing patients. Main Outcomes Measures Rate of change in global RNFL thickness. Results 39 subjects had evidence of unilateral progression by GPA and/or disc photographs during follow-up. Mean ± SE rate of RNFL loss in eyes progressing by conventional methods was −0.89 ± 0.22 μm/year; P < 0.001. The contralateral eyes of these subjects also showed significant loss of RNFL over time (−1.00 ± 0.20 μm/year; P < 0.001). 134 subjects did not show progression by conventional methods in either eye. These eyes also had significant decline over time in average RNFL thickness (−0.71 ± 0.09 μm/year; P < 0.001); however, the rate of change in these eyes was slower than the contralateral eye of patients showing unilateral progression (P < 0.001). Conclusion RNFL thickness loss was seen in a substantial number of the contralateral eyes of glaucoma patients showing unilateral progression by conventional methods. These findings indicate that assessment of RNFL thickness by SDOCT may show progressive glaucomatous damage that is not detected by visual fields or optic disc stereophotography.

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Section: Methodsmentioning

confidence: 69%

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods

Liu¹,

Tatham²,

Gracitelli³

et al. 2015

Ophthalmology

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“…SLP results are largely influenced by the scan status [20] and the polarizing properties of the cornea and crystalline lens, which may lead to spurious measurements [21]. It was shown that SLP with variable corneal compensation, SLP with enhanced cornea compensation, and SD-OCT RNFL measurements cannot be directly compared [22].…”

Section: Discussionmentioning

confidence: 99%

Peripapillary Retinal Nerve Fiber Layer Thicknesses Did Not Change in Long-term Hydroxychloroquine Users

Lee

Kim

Han

et al. 2018

Korean J Ophthalmol

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PurposeTo evaluate changes in the peripapillary retinal nerve fiber layer (RNFL) thicknesses using spectral-domain optical coherence tomography (SD-OCT) in hydroxychloroquine (HCQ) users.MethodsThe medical records of HCQ users were retrospectively reviewed. In these HCQ users, an automated perimetry, fundus autofluorescence photography, and SD-OCT with peripapillary RNFL thickness measurements were performed. The peripapillary RNFL thicknesses were compared between the HCQ users and the control groups. The relationships between the RNFL thicknesses and the duration or cumulative dosage of HCQ use were analyzed.ResultsThis study included 77 HCQ users and 20 normal controls. The mean duration of HCQ usage was 63.6 ± 38.4 months, and the cumulative dose of HCQ was 528.1 ± 3.44 g. Six patients developed HCQ retinopathy. Global and six sectoral RNFL thicknesses of the HCQ users did not significantly decrease compared to those of the normal controls. No significant correlation was found between the RNFL thickness and the duration of use or cumulative dose. The eyes of those with HCQ retinopathy had temporal peripapillary RNFL thicknesses significantly greater than that of normal controls.ConclusionsThe peripapillary RNFL thicknesses did not change in the HCQ users and did not correlate with the duration of HCQ use or cumulative doses of HCQ. RNFL thickness is not a useful biomarker for the early detection of HCQ retinal toxicity.

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“…[ 46 47 48 ] Diagnostic accuracy has been found to be comparable for SD-OCT and GDx-VCC if typical scans (TSS = 100) are investigated. [ 53 ] Decreasing TSS is associated with a decrease in diagnostic accuracy for discriminating healthy and glaucomatous eyes by SLP. NFI has been found to be less influenced than the global or sector RNFL thickness.…”

Section: Atypical Retardation Patternsmentioning

confidence: 99%

Scanning laser polarimetry in glaucoma

Dada

Sharma

Angmo

et al. 2014

Indian J Ophthalmol

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Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL). White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells. Hence, the measurement of RNFL thickness has come up. Optical coherence tomography and scanning laser polarimetry (SLP) are the techniques that utilize the evaluation of RNFL for the evaluation of glaucoma. SLP provides RNFL thickness measurements based upon the birefringence of the retinal ganglion cell axons. We have reviewed the published literature on the use of SLP in glaucoma. This review elucidates the technological principles, recent developments and the role of SLP in the diagnosis and monitoring of glaucomatous optic neuropathy, in the light of scientific evidence so far.

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Glaucoma Diagnostic Performance of GDxVCC and Spectralis OCT on Eyes With Atypical Retardation Pattern

Cited by 11 publications

References 26 publications

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods

Peripapillary Retinal Nerve Fiber Layer Thicknesses Did Not Change in Long-term Hydroxychloroquine Users

Scanning laser polarimetry in glaucoma

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