220 Drug Exposure and Risk of Microscopic Colitis - A Nationwide Danish Case-Control Study With 5751 Cases

Bonderup, Ole K.; Wigh, Tatjana; Vedsted, Peter; Nielsen, Gunnar Lauge

doi:10.1016/s0016-5085(13)60166-3

Cited by 36 publications

(76 citation statements)

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“…But the awareness for MC among both gastroenterologists and pathologists did increase enormously over the last decade. 34,35 Therefore, the figures in the last years of our study period are likely to reflect the true Dutch incidence rates, although still being low compared to other studies. Inclusion of the small number of subjects (n=70) with an unlikely diagnosis of MC would not have resulted in higher incidence rates.…”

Section: Discussionmentioning

confidence: 70%

“…33 Animal models in which bile duct ligation was performed, showed no intraluminal NSAIDs and no signs of gastrointestinal toxicity. 34 SSRIs and statins and MC An association was also found between current SSRI use and MC. In line with other studies, this was mainly explained by the association with LC.…”

Section: Non-steroidal Anti-inflammatory Drugs and MCmentioning

confidence: 80%

“…33 In theory, these drugs might therefore also influence the gastric-like proton pumps in vivo, which are suggested to be present in the colon. 34,35 However, the luminal pH of the colon is considered too alkaline to induce notable activation of any unchanged drug reaching the colon. 36 However, confirmative data on fecal concentrations of metabolized or unchanged PPIs are unavailable.…”

Section: Discussionmentioning

confidence: 99%

“…gastric and esophageal disorders, depressive mood disorder, chronic back pain and arthrosis) in the univariate and multivariable analyses could be due to residual confounding by MC associated drugs such as NSAIDs, PPIs, and selective serotonin reuptake Inhibitors (SSRI). 9,34 In theory this might also account for the association with cardiac disease, in which acetylsalicylic acid frequently is prescribed. 35 Unfortunately, analyses could not be corrected for drug exposure at index date (residual confounding), for drug exposure at the index date could not be assessed reliably based on patient medical files or the study questionnaire, particularly not in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…33 Since the mid-'90s, several population-based epidemiological studies on the incidence of MC have been published. [34][35][36][37][38][39][40][41][42][43] Although the majority originates from Europe and NorthAmerica, incidence rates from other parts of the world have also been published. [44][45][46] World-wide, pooled incidence rates of 4.1 and 4.9 per 100,000 person years have been reported for CC and LC, respectively.…”

Section: Epidemiologymentioning

confidence: 99%

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Section: Discussionmentioning

confidence: 70%

Section: Non-steroidal Anti-inflammatory Drugs and MCmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Epidemiologymentioning

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Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Pearlman

Covin

Schmidt

et al. 2017

The Journal of Clinical Pharma

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Several studies have reported constipation, abdominal pain, or diarrhea as common adverse events for statins. Statins are among the most commonly prescribed medications, and the impact on the prevalence of these conditions was rarely studied as main outcomes. The aim of this study is to determine if statin therapy is associated with constipation, abdominal pain, diarrhea, or colitis. This was a retrospective cohort study using a regional military health care data from October 1, 2003, to March 1, 2012. A propensity score-matched cohort of statin users and nonusers was created based on 82 variables. The primary analysis evaluated the odds ratios of the following diagnoses: constipation, ≥3 encounters for constipation; abdominal pain, ≥3 encounters for abdominal pain; diarrhea, ≥3 encounters for diarrhea; colitis, ≥3 encounters for colitis; and endoscopy of the lower gastrointestinal tract, ≥3 endoscopies of the lower gastrointestinal tract. After propensity score matching of 6342 statin users and 6342 nonusers, there was no statistically significant difference in constipation (OR, 0.96; 95%CI, 0.87-1.05; P = .33), abdominal pain (OR, 0.95; 95%CI, 0.88-1.02; P = .15), or colitis (OR, 1.02; 95%CI, 0.91-1.14; P = .73). However, there was an association between statin therapy and endoscopy of the lower gastrointestinal tract (OR, 1.14; 95%CI, 1.04-1.26; P = .002) and decreased odds of diarrhea (OR, 0.88; 95%CI, 0.80-0.97; P = .01). In this retrospective cohort study, an association between statin therapy and increased likelihood of being diagnosed with lower gastrointestinal conditions could not be demonstrated, contrary to some statins package inserts.

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220 Drug Exposure and Risk of Microscopic Colitis - A Nationwide Danish Case-Control Study With 5751 Cases

Cited by 36 publications

References 0 publications

Epidemiology of microscopic colitis

Epidemiology of microscopic colitis

Lymphocytic colitis–like pattern of mucosal injury and the challenges in diagnosing cancer immunotherapy‐related toxicity

Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

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