22. Non-Word Memory in Rett Syndrome and Rett-Related Disorders

Peters, Sarika U.; Jones, Dorita; Key, Alexandra P.

doi:10.1016/j.biopsych.2018.02.039

Cited by 2 publications

(4 citation statements)

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“…Previously, we demonstrated that during a passive paradigm, this response develops only for personally salient stimuli and can be observed both in typical and atypical populations (Key & Corbett, 2014; Key & Dykens, 2016, 2017). Significant correlations between the ERP marker of incidental memory for the repeated stimulus and the participants’ behavioral characteristics (e.g., Aberrant Behavior Checklist scores) further support the idea that ERPs can be a valid direct measure of the processes previously assessed using mainly indirect, informant-based tools (Peters et al, 2018; Key & Corbett, 2014). …”

Section: Introductionmentioning

confidence: 66%

“…Relative to the peak amplitude, mean amplitude metric is less susceptible to the effects of noise or variability in the number of artifact-free trials contributing to the averaged data (Luck, 2005). These spatial and temporal parameters were selected a priori based on our previous work examining incidental memory in persons with disabilities (Key & Corbett, 2014; Key & Dykens, 2016, 2017; Peters et al, 2018) and confirmed by visual inspection of the grand-averaged data. Significant stimulus-related effects were followed by two-tailed paired t- tests to test whether the repeated stimulus elicited more positive parietal amplitudes compared to the nonwords presented once.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we successfully used auditory ERPs in response to known or familiarized through repetition stimuli compared to novel distracters to document learning and memory in nonverbal individuals with other neurogenetic disorders, such as MECP2 duplication and Rett syndromes (Peters et al, 2015, 2017, 2018), the latter sharing several phenotypic features with AS. In particular, our auditory incidental memory paradigm allows to evaluate the extent of participant’s spontaneous engagement with auditory information.…”

Section: Introductionmentioning

confidence: 99%

“…Auditory ERPs during passive listening to a variety of spoken stimuli, from single syllables to complete words, have been previously used to document typical and atypical language functioning, make predictions regarding developmental outcomes, and to evaluate treatment effects in other neurodevelopmental disorders (Key et al, 2016; Maitre et al, 2013, 2014; Sandbank et al, 2017; Yoder et al, 2013). Recently, we successfully used auditory ERPs in response to known or familiarized through repetition stimuli compared to novel distracters to document learning and memory in nonverbal individuals with other neurogenetic disorders, such as MECP2 duplication and Rett syndromes (Peters et al, 2015, 2017, 2018), the latter sharing several phenotypic features with AS. In particular, our auditory incidental memory paradigm allows to evaluate the extent of participant’s spontaneous engagement with auditory information.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome

Key

Jones

Peters

et al. 2018

Brain and Cognition

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The combination of intellectual, communicative, and motor deficits limit the use of standardized behavioral assessments of cognition in individuals with Angelman syndrome (AS). The current study is the first to objectively evaluate learning and memory in AS using auditory event-related potentials (ERP) during passive exposure to spoken stimuli. Fifteen nonverbal individuals with the deletion subtype of AS (age 4–45 years) completed the auditory incidental memory paradigm. Auditory ERPs were recorded in response to a sequence of unfamiliar nonwords, in which one randomly selected stimulus was repeated multiple times and the rest were presented once. Larger parietal responses within 200–500ms for the repeated nonword compared to novel distracters were associated with caregiver reports of more adaptive communication skills. These findings demonstrate good tolerability of ERP procedures (94% success rate) and indicate that persons with AS can acquire new information following repeated auditory exposure, even in the absence of explicit memorization instructions. Strong associations between the caregiver reports of adaptive functioning and neural indices of auditory learning and memory support the utility of brain-based measures for objectively evaluating higher-order information processing in nonverbal persons with neurodevelopmental disorders.

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