[22] Chemical approaches toward generation of nitroxyl

“…Since Angeli's postulation, HNO (variously called nitroxyl, nitrosyl hydride, nitroso hydrogen, monomeric hyponitrous acid, hydrogen oxonitrate (IUPAC)) has been suggested to be an intermediate in a variety of oxidative processes involving nitrogen-containing compounds [10]. This is well illustrated by the extensive number of proposed mechanisms for HNO formation from inorganic and organic reactants (reviewed briefly in [11][12][13][14]). …”

Section: Introductionmentioning

confidence: 99%

Donors of HNO

Miranda

Nagasawa

Toscano

2005

CTMC

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Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.

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“…Nitrosyl hydride (HNO) [1][2][3] is isoelectronic with dioxygen, and the interaction of HNO with heme has been studied for many years [4][5][6]. Although it is generally accepted that nitric oxide (NO) is the final gaseous product of L L -arginine oxidation by the heme-containing enzyme NO synthase, there are some data that suggest that the primary product of the enzymatic conversion of L L -arginine to citrulline is HNO (reviewed in reference [7]).…”

mentioning

confidence: 99%