213th ENMC International Workshop: Outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18–20 September 2015

Aggarwal, Rohit; Allenbach, Yves; Benveniste, Olivier; Bleecker, Jan De; Groot, Ingrid de; Devilliers, H.; Hilton‐Jones, David; Hogrel, J.Y.; Lundberg, Ingrid E.; Mammen, Andrew L.; Oakley,; Oddis, Chester V.; Padberg, George W.; Ponce, D; Rider, Lisa G.; Rose, Mathew; Sanner, Helga; O'Callaghan, A. Selva-; Visser, Marjolein; Wells, Alvin F.; Werth, Victoria P.

doi:10.1016/j.nmd.2016.05.014

Cited by 20 publications

(15 citation statements)

References 94 publications

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“…However, there was no correlation between the mapping parameters and Troponin‐T, CK levels, or duration of the disease, which might be a result of the patient sample size. Meanwhile, it has been shown that the use of simple laboratory data to measure disease activity and outcomes is not appropriate in this patient population . For decades, the Disease Activity Core Set Measures developed by the International Clinical Assessment and Studies Group (IMACS) for IIM have been widely used, and these measures have also been used as clinical outcomes for IIM .…”

Section: Discussionmentioning

confidence: 99%

Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy

Sun

et al. 2018

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy

Sun

et al. 2018

Magnetic Resonance Imaging

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“…One limitation of this study might be the use of the SF‐12 rather than the SF‐36 for the assessment of HRQoL. The SF‐36 is the recommended HRQoL assessment tool and patient‐reported outcome measure for the evaluation of response to therapy in myositis by the International Myositis Assessment and Clinical Studies Group . Indeed, the SF‐12 has been used in only a few studies of HRQoL in IIM , which makes comparisons of results from this study to others more difficult.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are few sizable studies assessing HRQoL in patients with IIM . Due to the rarity of these conditions, previous studies had small sample sizes, which prohibited adequately powered statistical comparisons to delineate patient or IIM factors associated with HRQoL outcomes .…”

Section: Introductionmentioning

confidence: 99%

Predictors of Reduced Health‐Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies

Feldon

Farhadi

Brunner

et al. 2017

Arthritis Care & Research

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Objective Extensive studies on health-related quality of life (HRQOL) in idiopathic inflammatory myopathies (IIM) are lacking. Our objective was to document HRQOL and to identify factors associated with a reduced HRQOL in IIM patients. Methods A total of 1,715 patients (median age 49.9, 70% female, 87% Caucasian) who met probable or definite Bohan and Peter or Griggs criteria for myositis were included from the MYOVISION registry. HRQOL was ascertained via the SF-12v2® Health Survey questionnaire. HRQOL physical and mental summary scores (PCS and MCS, respectively) in relation to different patient and disease characteristics were compared to scores from the matched normative data from the U.S. general population and rheumatoid arthritis (RA) patients. Bivariate and multiple linear regression analyses were performed to assess the association between HRQOL and patient and disease parameters. Results The mean summary scores of the SF-12v2® were significantly lower in IIM as compared to the normative and RA populations. A diagnosis of inclusion body myositis, older age, patient-reported negative effect of disease on work, presence of another concurrent autoimmune disease, polypharmacy, and IIM-associated lung disease and joint involvement were all significantly associated with lower PCS scores. Lower MCS scores were associated with joint involvement and a negative effect on work. Conclusion In this large study of patient-reported outcomes in IIM, an association was found between multiple disease characteristics and reduced HRQOL, mostly in the physical domain. In the United States, HRQOL in IIM patients was lower compared to the general population and to RA patients.

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“…Un siècle plus tard les myopathies auto-immunes sont regroupées dans deux cadres nosologiques : celui de la polymyosite et celui de la dermatomyosite [2]. Aujourd'hui, de nombreux sous-groupes de myopathies inflammatoires ont été identifiés, grâce à des définitions histologiques plus précises, d'une part [3], et grâce à l'apport des auto-anticorps spécifiques des myosites, d'autre part. Il est important de souligner que quelle que soit la classification utilisée (histologique ou sérologique), les définitions reposent toujours sur atteinte musculaire bilatérale et diffuse.…”

Section: Introductionunclassified

Myosite focale : une maladie méconnue

Gallay

Streichenberger

Benveniste

et al. 2017

La Revue de Médecine Interne

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Focal myositis are inflammatory muscle diseases of unknown origin. At the opposite from the other idiopathic inflammatory myopathies, they are restricted to a single muscle or to a muscle group. They are not associated with extramuscular manifestations, and they have a good prognosis without any treatment. They are characterized by a localized swelling affecting mostly lower limbs. The pseudo-tumor can be painful, but is not associated with a muscle weakness. Creatine kinase level is normal. Muscle MRI shows an inflammation restricted to a muscle or a muscle group. Muscle biopsy and pathological analysis remain necessary for the diagnosis, showing inflammatory infiltrates composed by macrophages and lymphocytes without any specific distribution within the muscle. Focal overexpression of HLA-1 by the muscle fibers is frequently observed. The muscle biopsy permits to rule out differential diagnosis such a malignancy (sarcoma). Spontaneous remission occurs within weeks or months after the first symptoms, relapse is unusual.

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213th ENMC International Workshop: Outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18–20 September 2015

Cited by 20 publications

References 94 publications

Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy

Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy

Predictors of Reduced Health‐Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies

Myosite focale : une maladie méconnue

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213th ENMC International Workshop: Outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18–20 September 2015

Cited by 20 publications

References 94 publications

Early detection of myocardial involvement by T1 mapping of cardiac MRI in idiopathic inflammatory myopathy

Early detection of myocardial involvement by T1 mapping of cardiac MRI in idiopathic inflammatory myopathy

Predictors of Reduced Health‐Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies

Myosite focale : une maladie méconnue

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Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy

Early detection of myocardial involvement by T₁ mapping of cardiac MRI in idiopathic inflammatory myopathy