212Pb/212Bi Generator for nuclear medicine

Boldyrev, P. P.; Bortash, A. I.; Zagryadskii, V. A.; Zakharov, A. S.; Николаев, В. И.; Proshin, M. A.; Chuvilin, D. Yu.; Shatrov, A. V.; Vesnovskii, S. P.

doi:10.1007/s10512-012-9513-x

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…The 212 Bi generator is prepared by loading the 224 Ra onto a cation-exchange resin and 212 Bi eluted using 0.5–2 M HCl or HI. Elution of 212 Pb can be minimized by using lower acid concentration; however, both radionuclides are often eluted and labeled in transient equilibrium. − Interestingly, 212 Bi can also be obtained by isolating gaseous or aqueous 220 Rn; however, these methods have not been further explored due to limited 228 Th availability. − As discussed, the 212 Bi daughter, 208 Tl, emits high-energy, high-intensity gammas and places high shielding requirements on nuclear medicine staff. This is seen as a major drawback to clinical applicability of 212 Bi, and for this reason, 213 Bi is the preferred bismuth radioisotope and will be the focus of further discussion.…”

Section: Bismuthmentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Bismuthmentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…Recent successes in clinical trials with therapeutic isotope lead-212 ( 212 Pb)-labelled targeted alpha-radiopharmaceuticals are sparking significant interest in the consistent, facile, and large-scale acquisition of 212 Pb. [1][2][3] However, accelerator and reactor production stand as the primary means of obtaining numerous medical isotopes. 4,5 The necessity for specialized facilities and precise accelerator beam control significantly inflates the cost.…”

Section: Introductionmentioning

confidence: 99%

“…After 24 hours of stirring, the solvent was removed by vacuum distillation, and the solid product was washed with a 5% NaOH solution, resulting in a yield of 90%. DSADB18C6:1 H NMR (400 MHz, CDCl 3 ) δ 7.38 (d, J = 2.1 Hz, 2H), 7.23 (s, 2H), 6.87 (d, J = 1.4 Hz, 2H), 4.22-4.14 (m, 8H), 4.05-3.97 (m, 8H), 3.19 (q, J = 7.1 Hz, 8H), 1.10 (t, J = 7.1 Hz, 12H). 13 C NMR (101 MHz, CDCl 3 ) δ 151.57, 151.54, 148.27, 148.24, 132.03, 132.00, 120.77, 111.18, 110.33, 110.28, 69.25, 69.22, 69.20, 69.17, 68.33, 68.24, 41.87, 14.02.…”

mentioning

confidence: 99%

Separation of lead-212 from natural thorium solution utilizing novel sulfonamide dibenzo-18-crown-6

Cao,

Kang,

Tang

et al. 2024

Dalton Trans.

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“…In contrast, the indirect method involves extracting 228 Ra or 224 Ra from natural thorium and then making into generators for 212 Pb [19][20][21][22][23], which is widely adopted in the world. It https://doi.org/10.26434/chemrxiv-2024-0rwww ORCID: https://orcid.org/0000-0002-3053-9678 Content not peer-reviewed by ChemRxiv.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a mesoporous silica-based copolymer loaded with bis(2-ethylhexyl) phosphate for the efficient separation of trace radium from natural thorium

He,

Liao,

Tang

et al. 2024

Preprint

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Targeted α-nuclide therapy (TAT) has attracted significant attention in recent years due to its unique advantages in cancer treatment. As one of the most important TAT nuclides, 212Pb is quite rare and strongly depends on the supply of its parent nuclides with an appropriate half-life, such as 228Ra or 224Ra. Therefore, establishing a stable and effective method to obtain these nuclides is critical. To address this issue, a silica-supported copolymer loaded with bis (2-ethylhexyl) phosphate (HDEHP) was prepared, characterized, and investigated for the separation of 228Ra and 224Ra from natural 232Th in the nitric acid media. The experimental results showed that the adsorbent was prepared successfully with 19.5 wt% HDEHP loading, and possessed a small particle size and a porous structure. Compared with traditional cation exchange resin, the adsorbent exhibited ultrahigh selectivity and ultrafast adsorption kinetics towards thorium, with the equilibrium time less than 3 min. The adsorption isotherm was well described by the Langmuir model, and the maximum adsorption amount towards thorium could reach 72.0 mg/g. Thermodynamic investigations suggested that the thorium adsorption was endothermic and spontaneous. On basis of batch experiments, the separation behaviors were further investigated in column modes, and the separation of 228Ra and 224Ra from thorium was finally demonstrated using 226Ra as the tracer nuclide. The chemical recovery rate to 226Ra reached 96.7%, and the decontamination factor to thorium exceeded 105. The spectroscopic assessment suggested that the adsorbed species was mainly the positive Th4+ cation and almost no barium and nitrate ions were involved. The adsorption mechanism was dominated by compounding with oxygen in P-O-H and P=O groups. This work exhibited an excellent material and an efficient method for separating 228Ra and 224Ra from natural thorium, rendering it particularly significant in the future preparation and application of 212Pb.

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212Pb/212Bi Generator for nuclear medicine

Cited by 7 publications

References 6 publications

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

Separation of lead-212 from natural thorium solution utilizing novel sulfonamide dibenzo-18-crown-6

Preparation and characterization of a mesoporous silica-based copolymer loaded with bis(2-ethylhexyl) phosphate for the efficient separation of trace radium from natural thorium

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