“…Among hormone-producing cells, DEGs expressed by the Beta Cell population (n = 27 genes) included genes poorly characterized in beta cells (LMO2, ASPH), as well as known markers of beta cell identity (INS) (Wang et al, 2007) and function (IAPP, SLC30A8, PCSK1) (Pound et al, 2009); (Taylor et al, 2020); (Ramzy et al, 2020) (Figure 3E). Alpha Cells (n = 37 genes) expressed both known alpha cell-related genes, (IRX2, TTR), as well as genes whose function in alpha cells is not well characterized, such as EDN3, SPINT2, and CDNK1C.…”