2103 Molecular characterization of lupus nephritis kidneys and blood

Abstract

2103 Figure 1 Clustering of GSVA enrichment scores in lupus kidneys reveals four distinct endotypes of patients with LN. (a) Row and column hierarchical clustering of 76 patients with LN into four groups based upon gene expression of cellular and pathway gene modules. (b) Reordered clustering of LN patients in order of molecular disease severity from least to greatest. The columns represent individual patients that are grouped into four clusters (black, coral, yellow, and purple). The rows represent gene modules indicative of immune/inflammatory cells, nonhematopoietic cells, and cellular metabolism.