20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms

Baldwin, William S.; Bain, Lisa J.; Giulio, Richard Di; Kullman, Seth W.; Rice, Charles D.; Ringwood, Amy H.; Hurk, Peter van den

doi:10.1016/j.aquatox.2020.105620

Cited by 13 publications

(3 citation statements)

References 99 publications

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“…Occurrence of MPs in Adriatic food webs in different species (several fish and invertebrates including M. galloprovincialis) Avio et al [36] MPs MPs influence on marine organisms Baldwin et al [37] MPs Plastic impact on sharks and rays.…”

Section: Microplastic Particles and Textile Microfibersmentioning

confidence: 99%

Exploring the Impact of Contaminants of Emerging Concern on Fish and Invertebrates Physiology in the Mediterranean Sea

Impellitteri

Multisanti

Rusanova

et al. 2023

Biology

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In this historical context, the Mediterranean Sea faces an increasing threat from emerging pollutants such as pharmaceuticals, personal care products, heavy metals, pesticides and microplastics, which pose a serious risk to the environment and human health. In this regard, aquatic invertebrates and fish are particularly vulnerable to the toxic effects of these pollutants, and several species have been identified as bio-indicators for their detection. Among these, bivalve molluscs and elasmobranchs are now widely used as bio-indicators to accurately assess the effects of contaminants. The study focuses on the catshark Scyliorhinus canicular and on the Mediterranean mussel Mytilus galloprovincialis. The first one is a useful indicator of localised contamination levels due to its exposure to pollutants that accumulate on the seabed. Moreover, it has a high trophic position and plays an important role in the Mediterranean Sea ecosystem. The bivalve mollusc Mytilus galloprovincialis, on the other hand, being a filter-feeding organism, can acquire and bioaccumulate foreign particles present in its environment. Additionally, because it is also a species of commercial interest, it has a direct impact on human health. In conclusion, the increasing presence of emerging pollutants in the Mediterranean Sea is a serious issue that requires immediate attention. Bivalve molluscs and elasmobranchs are two examples of bio-indicators that must be used to precisely determine the effects of these pollutants on the marine ecosystem and human health.

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Section: Microplastic Particles and Textile Microfibersmentioning

confidence: 99%

Exploring the Impact of Contaminants of Emerging Concern on Fish and Invertebrates Physiology in the Mediterranean Sea

Impellitteri

Multisanti

Rusanova

et al. 2023

Biology

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“…Some common long chain fluorosurfactants such as PFOS and PFOA were phased out of production in the USA and Europe because of their long half-lives, with a few exemptions. However, PFOS has continued to cause adverse health effects due to its bioaccumulation [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression

Williams,

Hamilton,

Edin

et al. 2024

Toxics

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Perfluorooctanesulfonate (PFOS) is a widespread environmental pollutant with a long half-life and clearly negative outcomes on metabolic diseases such as fatty liver disease and diabetes. Male and female Cyp2b-null and humanized CYP2B6-transgenic (hCYP2B6-Tg) mice were treated with 0, 1, or 10 mg/kg/day PFOS for 21 days, and surprisingly it was found that PFOS was retained at greater concentrations in the serum and liver of hCYP2B6-Tg mice than those of Cyp2b-null mice, with greater differences in the females. Thus, Cyp2b-null and hCYP2B6-Tg mice provide new models for investigating individual mechanisms for PFOS bioaccumulation and toxicity. Overt toxicity was greater in hCYP2B6-Tg mice (especially females) as measured by mortality; however, steatosis occurred more readily in Cyp2b-null mice despite the lower PFOS liver concentrations. Targeted lipidomics and transcriptomics from PFOS-treated Cyp2b-null and hCYP2B6-Tg mouse livers were performed and compared to PFOS retention and serum markers of toxicity using PCA. Several oxylipins, including prostaglandins, thromboxanes, and docosahexaenoic acid metabolites, are associated or inversely associated with PFOS toxicity. Both lipidomics and transcriptomics indicate PFOS toxicity is associated with PPAR activity in all models. GO terms associated with reduced steatosis were sexually dimorphic with lipid metabolism and transport increased in females and circadian rhythm associated genes increased in males. However, we cannot rule out that steatosis was initially protective from PFOS toxicity. Moreover, several transporters are associated with increased retention, probably due to increased uptake. The strongest associations are the organic anion transport proteins (Oatp1a4-6) genes and a long-chain fatty acid transport protein (fatp1), enriched in female hCYP2B6-Tg mice. PFOS uptake was also reduced in cultured murine hepatocytes by OATP inhibitors. The role of OATP1A6 and FATP1 in PFOS transport has not been tested. In summary, Cyp2b-null and hCYP2B6-Tg mice provided unique models for estimating the importance of novel mechanisms in PFOS retention and toxicity.

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“…Understanding the environmental impact of oilfield chemicals, particularly on fish populations, is critical for developing effective mitigation techniques. Genetic alterations or responses in organisms such as C. gariepinus could have significant effects on population health and ecosystem dynamics due to environmental stressors (Baldwin et al, 2020;Turan et al, 2020;Świacka et al, 2021;Nwizugbo et al, 2023). This research aims to investigate the genetic responses of C. gariepinus to varied amounts of xylene: diesel and oilfieldbased emulsifiers, establishing a relationship between DNA modifications, ecotoxicological effects, and possible evolutionary ramifications.…”

Section: Introductionmentioning

confidence: 99%

Assessment of genotoxicity in Clarias gariepinus exposed to lethal and sub-lethal concentrations of oilfield chemicals: DNA concentration, purity, and genetic implications

Davies Ibienebo Chris,

Ebere Samuel Erondu,

Davies Imachrist Ibienebo

2024

Open Access Res. J. Sci. Technol.

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This study investigates the concentration and purity of DNA extracted from Clarias gariepinus after exposure to lethal concentrations (250 ml/l, 200 ml/l, 150 ml/l, 100 ml/l, 50 ml/l, 25 ml/l and 0.0 ml/l for the control) of Xylene: Diesel (X:D) and Oilfield-Based Emulsifiers (O-BE) over 96 hours using static bioassays and sub-lethal concentrations 0 ml/l (control), 12.8 ml/l, 25.6 ml/l, 38.4 ml/l, 51.2 ml/l and 64.0 ml/l) using renewal bioassay for 28 days. 210 juveniles were used for the experiment. The study used PCR and other methods to analyse DNA concentrations and purity in the fish samples. The results indicated variations in DNA concentration, purity, and the presence of micronuclei, suggesting genetic and cytogenetic responses to chemical exposures. The highest DNA concentration was recorded in the 25 ml/l group for both O-BE and X:D, while the lowest was in the 100 ml/l group. The genetic effects of Xylene: Diesel on the molecular level were also examined, with significant gaps in the alignments of experimental groups indicating notable differences in the sequences compared to the control group without chemical exposure. Through detailed analyses, including gel electrophoresis and sequence alignment, the study explores genetic variations and micronuclei frequencies in blood cells, shedding light on the ecotoxicological impacts and potential evolutionary implications of these oil-based substances on African catfish. Understanding the genetic variations induced by lethal concentrations of O-BE in Clarias gariepinus is crucial for assessing the broader environmental impact, as genetic changes in aquatic organisms can affect population health, adaptation, and ecosystem dynamics.

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20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms

Cited by 13 publications

References 99 publications

Exploring the Impact of Contaminants of Emerging Concern on Fish and Invertebrates Physiology in the Mediterranean Sea

Exploring the Impact of Contaminants of Emerging Concern on Fish and Invertebrates Physiology in the Mediterranean Sea

Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression

Assessment of genotoxicity in Clarias gariepinus exposed to lethal and sub-lethal concentrations of oilfield chemicals: DNA concentration, purity, and genetic implications

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