Current chemotherapeutic options for the treatment of advanced bladder cancer: A review

Pliarchopoulou, Kyriaki; Laschos, Konstantinos; Pectasides, Dimitrios

doi:10.1016/j.urolonc.2010.07.011

Cited by 15 publications

(10 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such drugs, however, yield poor oncological outcomes and show high toxicity (4), and there is growing interest in other types of therapeutic agents for the treatment of advanced bladder cancer (4). The development of more effective and less toxic therapeutic regimens is vital for the improvement of survival among patients with bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Anticancer effect of S‑allyl‑L‑cysteine via induction of apoptosis in human bladder cancer cells

Kang

Lee

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract.To exa m i ne the anticancer effects of S-allyl-L-cysteine (SAC) in human bladder cancer cells and to identify possible molecular mechanisms, bladder cancer cell lines (HTB5, HTB9, JON, UMUC14, T24, and cisplatin resistant-T24R2) were incubated with SAC, and cell proliferaproliferation was measured using the Cell Counting Kit-8 assay and clonogenic assay. Cell cycle and apoptosis were evaluated by flow cytometry. Expression levels of apoptosis-and cell cycle-associated proteins were analyzed by western blotting. Proliferation and colony formation in bladder cancer cells was significantly inhibited by SAC treatment in a dose-dependent manner. SAC treatment significantly enhanced apoptosis and promoted a cell cycle arrest in the S phase. SAC also increased the expression of apoptosis-related genes, including caspases, poly (ADP-ribose) polymerase and cytochrome c. SAC had an anticancer effect on bladder cancer cells in vitro, at least partially, through the induction of apoptosis and a cell cycle arrest. SAC is a potential therapeutic agent for the treatment of bladder cancer. IntroductionUrinary bladder cancer is a common malignancy of the urinary tract and responsible for 150,000 deaths annually. Urinary bladder cancer is the seventh most prevalent type of cancer worldwide (1). In Korea, the number of cases of urinary bladder cancer increased from 2,180 in 1999 to 3,549 in 2011 (2). The incidence of urinary bladder cancer is four times higher in men compared with women (3).Cisplatin-based combination chemotherapy is widely used against advanced and metastatic bladder cancer. Such drugs, however, yield poor oncological outcomes and show high toxicity (4), and there is growing interest in other types of therapeutic agents for the treatment of advanced bladder cancer (4). The development of more effective and less toxic therapeutic regimens is vital for the improvement of survival among patients with bladder cancer.Recent studies showed that natural bioactive compounds, including isothiocyanate and amygdalin, have anticancer effects on bladder cancer cells (5,6). Garlic, a species of the Allium genus, has been utilized for medicinal purposes in recorded history (7-9). Organosulfur compounds from Allium vegetables have been reported to have possible preventive and therapeutic properties against some types of cancer (7). Sulfur-containing compounds in garlic can be broadly categorized as oil-soluble (diallylsulphide, diallyldisulphide and diallyltrisulfide) or water-soluble [S-allyl-L-cysteine (SAC)] (8). SAC is the most abundant organosulfur compound in aged-garlic extract and was reported to have antioxidant, and neuroprotective properties as well as anticancer activity (9-11). Several studies showed that SAC has anticancer effects by suppressing the cellular proliferation and metastasis and induces apoptosis in a number of cancer models, including ovarian, prostate and hepatocellular carcinoma (7-9). Nevertheless, whether SAC has anticancer effects in bladder cancer remains an open question.In the present...

show abstract

Section: Introductionmentioning

confidence: 99%

Anticancer effect of S‑allyl‑L‑cysteine via induction of apoptosis in human bladder cancer cells

Kang

Lee

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Therapeutic options for bladder cancer include surgical resection, intravascular chemotherapy, radiation, immunotherapy and system chemotherapy. Despite the low-grade cases (good differentiation) having an excellent prognosis, high-grade cases (medium and poor differentiation) progress to invasion, metastases and death (11). Therefore, identifying novel and alternative therapeutic strategies is critical for prolonging survival.…”

Section: Introductionmentioning

confidence: 99%

ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer

Tao

Meng

Zheng

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Ellipticine, an alkaloid isolated from Apocyanaceae plants, has been demonstrated to exhibit antitumor activity in several cancers. However, the effect and the mechanisms underlying its action have not been investigated in human bladder cancer cells. The aim of the present study was to investigate the effect and mechanism of ellipticine on the behavior of T-24 bladder cancer cells. T-24 cells were treated with varying concentrations and durations of ellipticine. Cell viability was evaluated by Cell Counting Kit-8 assay. Cell motility was analyzed by Transwell migration assay. Flow cytometry, reverse transcription-quantitative polymerase chain reaction and western blot analyses were performed to detect the cell cycle and signaling pathways involved. The results demonstrated that ellipticine suppressed proliferation and inhibited the migration ability of T-24 bladder cancer cells in a dose- and time-dependent manner, and resulted in G2/M cell cycle arrest. The mechanism of this action was demonstrated to be due to ellipticine-triggered activation of the ATM serine/threonine kinase pathway. These data therefore suggest that ellipticine may be effective towards treating human bladder cancer.

show abstract

“…The majority of BC is represented by urothelial carcinoma (UC), also known as transitional cell carcinoma (TCC), while squamous and adenocarcinomas are diffused in a small percentage [1]. Although BC is considered to be responsive to the chemotherapy regiments, only few patients respond to single-agent therapy.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

et al. 2016

View full text Add to dashboard Cite

Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC cells.Here we found that treatment of high-grade BC cells with high dose of CPS triggers autophagy. Infact, the CPS treatment alters the redox homeostasis by inducing production of radicals, mitochondrial depolarization, alterations of ADP/ATP ratio and activation of AMPK pathway stimulating the autophagic process in BC cells. The inhibition of autophagy, by using the specific inhibitor bafilomycin A or Beclin 1 knock-down, enhanced the CPS-induced cell death, demonstrating that CPS-induced autophagy acts as a pro-survival process in BC cells. By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, α5 and β1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins. Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels. By PTCH2 knock-down we found that the Hedgehog signaling pathway is involved in the CPS-induced autophagy and EMT phenotype.Finally, we also showed that the CPS-resistant EMT-positive BC cells displayed an increased drug-resistance to the cytotoxic effects of mitomycin C, gemcitabine and doxorubicine drugs commonly used in BC therapy.

show abstract

Current chemotherapeutic options for the treatment of advanced bladder cancer: A review

Cited by 15 publications

References 89 publications

Anticancer effect of S‑allyl‑L‑cysteine via induction of apoptosis in human bladder cancer cells

Anticancer effect of S‑allyl‑L‑cysteine via induction of apoptosis in human bladder cancer cells

ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

Contact Info

Product

Resources

About