206The novel oral protein prenyl transferase inhibitor AZD3409 inhibits prostate epithelial cell proliferation and invasion in vitro, without bone marrow toxicity

Khafagy, Richard; Stephens, T C; Hart, Claire A.; Brown, M.; Clarke, N.

doi:10.1016/s1569-9056(05)80214-3

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Distal Attachment and Tumour Cell Transmigration Through The2

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“…This inhibitory effect has been demonstrated in vitro in PCa using zoledronic acid [25] and the prenylation inhibitor AZD3409 [33,55]. The inhibitory effects of these compounds are known to be related to Rho through its interaction with Ras [56].…”

Section: Distal Attachment and Tumour Cell Transmigration Through Thementioning

confidence: 99%

Molecular mechanisms of metastasis in prostate cancer

Clarke

Hart²,

Brown³

2008

Asian J Androl

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Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.

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Section: Distal Attachment and Tumour Cell Transmigration Through Thementioning

confidence: 99%

Molecular mechanisms of metastasis in prostate cancer

Clarke

Hart²,

Brown³

2008

Asian J Androl

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show abstract

“…The effect of Ras-Rho inhibition of reducing the propensity of PECs to invade across endothelial barriers suggests that a major component affecting cancer cell migration is inhibition of transduction pathways related to the Rho axis. This inhibitory effect has been demonstrated in vitro in PCa using zoledronic acid [25] and the prenylation inhibitor AZD3409 [33,55]. The inhibitory effects of these compounds are known to be related to Rho through its interaction with Ras [56].…”

Section: Distal Attachment and Tumour Cell Transmigration Through The Endotheliummentioning

confidence: 99%