203P: Could neutrophil-to-lymphocyte ratio be predictor of brain metastases in non small cell lung cancer?

Serdarević, Marina; Kukulj, Suzana; Nikolić, Igor; Taradi, Ida; Romić, Željko; Samaržija, Miroslav

doi:10.1016/s1556-0864(16)30311-2

Cited by 5 publications

(6 citation statements)

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“…Templeton et al, allege that high NLR has an adverse effect on overall survival (OS) in many solid tumours [27], and this result was also agreeable with the previous study by Serdarevic et al, [28] on BM and non-BM population of non-small-cell lung cancer (NSCLC) which conclude higher NLR mean on BM group and more progressive condition (6.05 vs 4.6, p = 0.023) [28]. This was also confirmed by another prognostic study of NLR that elevated preoperative NLR is a predictor of worse survival after BM resection (OS 14 month for NLR < 5 and 5 months for NLR ≥ 5, p = 0.001) [27], [29].…”

Section: Discussionsupporting

confidence: 87%

Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis

Ritarwan¹,

Nasution²,

Erwin³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:As the most cause of death in patients with solid extracranial malignancy, brain metastasis (BM) nowadays being studied extensively especially on how to find a reliable laboratory marker that can correlate with its clinical outcome. Leukocyte subtypes, primarily neutrophils and lymphocytes and its ratio known as Neutrophils-Lymphocyte Ratio (NLR) have been known before its relationship with progressivity of BM from other solid tumours.AIM:The objectives of this research to study the correlation of leukocyte subtypes, neutrophil-lymphocyte ratio & functional outcome in brain metastasis.METHODS:The study subjects were recruited consecutively from the study population. Venous blood was taken 5 ml of venous blood samples done in the first day of admission on emergency department and neurology clinic of Neurology Department of Adam Malik General Hospital before any drug injections. Samples were kept in vacutainer tubes containing ethylenediaminetetraacetic acid (EDTA) and sent to Department of Clinical Pathology laboratory of Adam Malik General Hospital, immediately centrifuged at 3100 rpm for 10 minutes in -20°C temperature and analysed using Sysmex XT-2000i. Functional outcome of the patient assessed using Karnofsky performance scale (KPS) in a cross-sectional manner with laboratory analysis.RESULTS:We conduct a mean differences and correlational leukocytes and its subsets analysis of 72 BM patients resulting on significant positive correlation on lymphocyte percentage (r = 0.383, p = 0.001) and lymphocyte absolute (r = 0.265, p = 0.024), also significant negative correlation on neutrophils (r = -0.240, p = 0.042) and NLR (r = -0.432, p < 0.001) with Karnofsky Performance Scale (KPS).CONCLUSION:Increased lymphocyte absolute and lymphocyte percentage correlated significantly (p < 0.05) with better KPS, while elevated neutrophils percentage and increased NLR show significant correlation with worse outcome of BM patients.

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Section: Discussionsupporting

confidence: 87%

Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis

Ritarwan¹,

Nasution²,

Erwin³

et al. 2018

Open Access Maced J Med Sci

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“…Many hematological biomarkers reflecting systemic inflammatory response has been suggested as independent prognostic biomarkers, such as, PLR, NLR, and LMR. [ 11 – 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, accumulating evidence suggested that inflammation played an important role in cancer growth and metastasis, and had a prognostic significance in a variety of cancers. [ 9 – 11 ] Some inflammatory biomarkers in peripheral blood, such as neutrophil count, lymphocyte count, platelet lymphocyte ratio, neutrophil lymphocyte ratio, and lymphocyte monocyte ratio (LMR) have been proposed to predict cancer outcome. [ 11 – 13 ] LMR has been shown to be related to the prognosis of various cancers, such as hepatocellular carcinoma, [ 14 ] esophageal squamous cell carcinoma, [ 15 ] Hodgkin lymphoma, [ 16 ] urothelial cancers.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of lymphocyte monocyte ratio in patients with ovarian cancer

2020

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Background: This study aimed to systematically assess the prognostic value of lymphocyte monocyte ratio (LMR) in patients with ovarian cancer through performing a meta-analysis. Methods: Web of Science, PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure databases were searched for potentially eligible studies. The baseline characteristics and relevant data were extracted. Hazard ratios with 95% confidence intervals (CIs) were combined to assess the prognostic value of LMR in patients with ovarian cancer. Results: Nine studies enrolling 2809 patients were included. The pooled hazard ratios of lower LMR for overall survival and progression free survival in patients with ovarian cancer were 1.71 (95% CI, 1.40–2.09) and 1.68 (95% CI, 1.49–1.88), respectively. Subgroup analysis and sensitivity analysis were also performed. No significant publication bias was found. Conclusion: Our results suggested that lower LMR was associated with poorer overall survival and progression free survival in patients with ovarian cancer. The findings may assist prognosis evaluation and future research on therapies based on modulating host immune response in ovarian cancer.

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“…DC vaccinations such as DCVax-L have shown promising results, and as a consequence are in advanced clinical trials (newly-diagnosed glioblastoma, NCT00045968, Phase III) (Prins et al, 2011). Neutrophils also hold potential for their prognostic value in patients with primary brain tumors (Bertaut et al, 2016; Fossati et al, 1999), and metastatic disease (Koh et al, 2016; Mitsuya et al, 2016; Serdarevic et al, 2016). Targeting the vasculature through anti-angiogenic strategies is also relevant in glioblastoma patients given that this tumor type is highly vascularized; however, the current evidence seems to suggest that these strategies may be optimally used in the recurrent setting in combination with additional therapies (Friedman et al, 2009; Kreisl et al, 2009), rather than as frontline monotherapy on newly diagnosed, untreated disease (Gilbert et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Microenvironmental Landscape of Brain Tumors

2017

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The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.

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203P: Could neutrophil-to-lymphocyte ratio be predictor of brain metastases in non small cell lung cancer?

Abstract: Abstracts, ELCC 2016 -Metastases to and from the lung S145 outcome (0.38, 0.9, and 0.3). However, on multivariate analysis, pleural effusion and brain mets significantly impacted outcome (p = 0.09, 0.0008).

Cited by 5 publications

References 0 publications

Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis

Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis

Prognostic significance of lymphocyte monocyte ratio in patients with ovarian cancer

The Microenvironmental Landscape of Brain Tumors

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