2022-RA-958-ESGO Invasive stratified mucin-producing intraepithelial lesion (iSMILE) a rare entity of cervical cancer

Abstract

Methodology Eligible patients had FIGO 2009 stage IB2-IIIB cervical cancer with no or only limited (£5 mm) vaginal involvement. Comprehensive assessment of vaginal changes was done before treatment, at 4-6 weeks and 3, 6, 12 and 24 months thereafter using CTCAE v3.0 and additional assessments. PRO were assessed at the same timepoints using validated Quality of Life (EORTC QLQ-C30 and CX24) and sexual questionnaires. Statistical methods included generalized linear mixed model analysis and Spearman's rho correlation coefficients.