2022-RA-646-ESGO Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma, an international delphi study

Abstract

while the negative predictive value (NPP) reached 92.77% (95% CI: 89.56% -95.04%). In general, the diagnostic accuracy of the cytological evaluation reaches 74.93% (95% CI: 66.99% -79.43%).

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions

“…Classic morphologic features of STICs include nuclear atypia, prominent nucleoli, epithelial stratification, and occasional mitotic figures and/or apoptotic bodies. [10][11][12] STICs can be found with or without concurrent HGSC, and isolated STICs detected incidentally, in the absence of HGSC, arguably provide the ideal tissue sources for studying the pathogenesis of HGSC. Alongside STIC that may represent the immediate precursor of many HGSCs, other related lesions have been recognized.…”