2020 list of human papillomavirus assays suitable for primary cervical cancer screening

Arbyn, Marc; Simon, Marie; Peeters, Eliana; Xu, Lan; Meijer, Chris J.L.M.; Berkhof, Johannes; Cuschieri, Kate; Bonde, Jesper; Vanlencak, Anja Ostrbenk; Zhao, Fen; Rezhake, Remila; Gültekin, Murat; Dillner, Joakim; Sanjosé, Sílvia de; Canfell, Karen; Hillemanns, Peter; Almonte, Maribel; Wentzensen, Nicolas; Poljak, Mario

doi:10.1016/j.cmi.2021.04.031

Cited by 128 publications

(125 citation statements)

References 96 publications

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“…Moreover, the list of known HR-HPVs could change in the next years as the genotypes contained in the vaccine. Arbyn et al (46,47) suggested increasing the HR-HPVs in the list from 14 up to 20 due to the growing carcinogenicity of potential/possible risk types. The phenomenon of growing carcinogenicity, including the ability of constant evolution of HPV types, should be considered (48).…”

Section: Discussionmentioning

confidence: 99%

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

et al. 2021

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A comprehensive literature review was performed to determine the relationship between HPV infection and infertility and the eventual role of the 9-valent vaccine for infertility prevention. The search was extended from January 1997 through July 2021. Data collected from selected articles focused on three main topics: statistical associations between HPV prevalence and assisted reproductive technology (ART) outcome, association between HPV and characteristics of semen, and associations between HPV and miscarriage. Articles that identified HPV genotypes were selected for this review to study the possible role of the 9-valent vaccine in infertility prevention. To date, there is no agreement on the implication HPV female infection has on the fertility and miscarriage rate. Although it can be stated that HPV prevalence among couples with infertility undergoing ART treatment is consistent, it does not seem to affect the performance of oocytes. Otherwise, HPV infection affects sperm parameters, in particular spermatozoa motility. When an association can be found, most cases of HR-HPV involved are those included in the 9-valent vaccine. The correlation between HPV male infection both with asthenozoospermia and increased risk of pregnancy loss could recommend the extension of anti-HPV vaccination to adolescent males along with cancer prevention. Despite the fact that the relation between 9-valent HPV genotypes involved in female infection and miscarriage/infertility is not clear, the impact of this virus on health reproduction is evident. Considering this, the importance of HPV vaccination in adolescent females is confirmed. A vaccine efficacy study could be useful to confirm the importance of primary prevention for couple reproductive health.

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Section: Discussionmentioning

confidence: 99%

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

et al. 2021

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“…Despite studies demonstrating that HPV testing has a lower specificity (89.9%) than cytology (96.3%) for CINII, this screening method still has a number of advantages ( 66 ). However, in accordance with the most recent guidelines, primary HPV testing must be performed by assays targeting all the high-risk types (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 68), that have been clinically validated according to the international recommendations published in 2009 and in a recent study by Arbyn et al ( 67 ), a list of 11 DNA assays fulfilled all requirements in order to serve as a primary screening tool.…”

Section: Recent Developments In Screening Methodsmentioning

confidence: 99%

Cervical cancer, geographical inequalities, prevention and barriers in resource depleted countries (Review)

2022

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Cervical cancer (CC) remains a current global issue, with >90% of cervical cancer cases being attributed to human papilloma virus (HPV). The highest burden of cervical cancer is reported in resource-depleted geographical areas with a high incidence of HPV infection. Recent developments in primary prevention include vaccinations against specific strains of HPV and the psychoeducation of the public. Yet, despite the availability of vaccinations, there is high incidence of both HPV and cervical cancer in developing countries, which is attributed to a multitude of barriers including inaccessibility to expensive vaccines. With regards to secondary prevention, progress is actively being made to develop more effective methods of screening and to specifically address the needs of low-income countries. In the past few years, more novel screening methods, such as self-assessment kits, immunohistochemistry and methylation marker analysis, have been developed. Barriers to screening in resource-depleted countries include limited financial resources and infrastructure to develop screening programmes, a lack of screening programmes that are accessible to populations, inadequate training of healthcare teams and stigma related to medical examinations performed as part of screening. Developing primary and secondary prevention programs, as well as addressing the barriers involved in countries with low socioeconomic levels, can drastically reduce morbidity and mortality rates associated with cervical cancer, thus reducing the burden associated with this gynaecological malignancy. Contents1. Introduction 2. Epidemiology and geographical inequalities in the burden of CC 3. Primary prevention and barriers faced by developing countries 4. Vaccinations 5. Psychoeducation 6. Secondary prevention and challenges faced by developing countries 7. Recent developments in screening methods 8. Barriers to screening in low resource countries and strategies for improvement 9. Conclusion

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“…Both cervical neoplasia and cervical cancer have profound impacts on the health and quality of life of affected women [5,6]. Several strategies have been developed for the prevention and early detection of cervical dysplasia, among them human papilloma virus (HPV) vaccination, HPV testing, and cervical cytology using Papanicolaou smears [1,[7][8][9]. For further evaluation of women with suspected cervical dysplasia, cervical colposcopy is the standard diagnostic instrument as recommended by professional societies when at least one abnormal cytological result is observed [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Sequential Application of Lugol’s Iodine Test after Acetic Acid for Detecting Cervical Dysplasia: A Prospective Cohort Study

et al. 2021

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Applying Lugol’s iodine solution to the cervix followed by colposcopic assessment is an established standard test to identify low grade/high grade squamous intraepithelial lesions (LSIL/HSIL). Here, we assessed the performance of Lugol’s iodine test during colposcopy using a standardized protocol with 5% acetic acid followed by 5% Lugol’s iodine solution and recording the most severe acetowhite (MSAWL) and iodine-negative (MSINL) lesions in a prospective cohort of consecutive women referred to our specialized colposcopy unit. The primary study endpoint was the sensitivity/specificity of MSINL for the detection of LSIL/HSIL. Secondary endpoints were the time to first appearance of the MSINL, MSINL staining intensity, and fading of MSINL. Three hundred and twenty women were included. The sensitivity and specificity of MSINL for the detection of LSIL/HSIL was 81.4 (95%—confidence interval (CI) 77.3–85.0)% and 29.5 (24.2–35.5)%, respectively. Ninety-six MSINL were identified exclusively by Lugol’s iodine test (no pathology, n = 46; LSIL, n = 29; HSIL, n = 21) (number needed to biopsy to identify one additional LSIL/HSIL = 1.9). In 17/320 (5.3%) patients, the clinical management was changed based on the result of Lugol’s iodine test. Video analysis showed an instant appearance of the MSINL within 10 s in 100% of cases. Intensity of MSINL significantly correlated with the presence/absence of LSIL/HSIL (Spearman rank order correlation; p < 0.0001). Fading of iodine-induced staining intensity over time was not observed. Thus, Lugol’s iodine showed moderate sensitivity and poor specificity, but changed clinical management in 5% of cases when used in addition to acetic acid.

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2020 list of human papillomavirus assays suitable for primary cervical cancer screening

Cited by 128 publications

References 96 publications

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

The Impact of 9-Valent HPV Vaccination on Couple Infertility Prevention: A Comprehensive Review

Cervical cancer, geographical inequalities, prevention and barriers in resource depleted countries (Review)

Sequential Application of Lugol’s Iodine Test after Acetic Acid for Detecting Cervical Dysplasia: A Prospective Cohort Study

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