2019 American Thoracic Society BEAR Cage Winning Proposal: Lung Imaging Using High-Performance Low-Field Magnetic Resonance Imaging

Campbell-Washburn, Adrienne E

doi:10.1164/rccm.201912-2505ed

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…Low field MRI might overcome some of the important limitations mentioned: First, as implied by the technique, it is a radiation-free imaging method, thus concerns about repetitive examinations using CT can be resolved. Second reduced susceptibility effects at air-tissue interfaces at low field MRI result in a higher signal intensity of lung parenchyma, which might significantly improve lung imaging in MRI as compared to higher field strengths [ 5 , 6 ]. Further, which might be considered one of the most important advantages of using MRI for pulmonary imaging is the capability to provide tissue characterization beyond the limits of the CT.…”

Section: Discussionmentioning

confidence: 99%

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19

Heiß

Grodzki

Horger

et al. 2021

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19

Heiß

Grodzki

Horger

et al. 2021

Magnetic Resonance Imaging

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“…Recently, we described a 0.55 T MRI configuration with contemporary hardware and software that offers opportunities for lung imaging 13,14 . This low‐field MRI configuration provides improved B 0 field homogeneity, and associated prolonged T 2 *.…”

Section: Introductionmentioning

confidence: 99%

Oxygen‐enhanced functional lung imaging using a contemporary 0.55 T MRI system

et al. 2021

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The purpose of this study was to evaluate oxygen‐enhanced pulmonary imaging at 0.55 T with 3D stack‐of‐spirals ultrashort‐TE (UTE) acquisition. Oxygen‐enhanced pulmonary MRI offers the measurement of regional lung ventilation and perfusion using inhaled oxygen as a contrast agent. Low‐field MRI systems equipped with contemporary hardware can provide high‐quality structural lung imaging by virtue of the prolonged T2*. Fortuitously, the T1 relaxivity of oxygen increases at lower field strengths, which is expected to improve the sensitivity of oxygen‐enhanced lung MRI. We implemented a breath‐held T1‐weighted 3D stack‐of‐spirals UTE acquisition with a 7 ms spiral‐out readout. Measurement repeatability was assessed using five repetitions of oxygen‐enhanced lung imaging in healthy volunteers (n = 7). The signal intensity at both normoxia and hyperoxia was strongly dependent on lung tissue density modulated by breath‐hold volume during the five repetitions. A voxel‐wise correction for lung tissue density improved the repeatability of percent signal enhancement maps (coefficient of variation = 34 ± 16%). Percent signal enhancement maps were compared in 15 healthy volunteers and 10 patients with lymphangioleiomyomatosis (LAM), a rare cystic disease known to reduce pulmonary function. We measured a mean percent signal enhancement of 9.0 ± 3.5% at 0.55 T in healthy volunteers, and reduced signal enhancement in patients with LAM (5.4 ± 4.8%, p = 0.02). The heterogeneity, estimated by the percent of lung volume exhibiting low enhancement, was significantly increased in patients with LAM compared with healthy volunteers (11.1 ± 6.0% versus 30.5 ± 13.1%, p = 0.01), illustrating the capability to measure regional functional deficits.

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“…Possible explanations for this phenomenon are the relatively low proton density of ground-glass opacities relative to that of consolidations, signal loss due to T2* decay, and cardiac motion. Promising results regarding the visualization of ground-glass opacities have been reported for low-field MRI, the low susceptibility of which results in higher signal intensity of lung parenchyma, as well as for respiratory-gated ultra-short echo time (UTE) MRI, which is less susceptible to T2* decay and motion artifacts than are other sequences (22,25) . Yang et al (14) examined the potential of UTE-MRI and CT for assessing COVID-19 pneumonia and reported that the two modalities provide similar image quality and high concordance for assessing the representative image findings.…”

Section: Discussionmentioning

confidence: 99%

Appearance of COVID-19 pneumonia on 1.5 T TrueFISP MRI

et al. 2021

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Objective: To evaluate the performance of 1.5 T true fast imaging with steady state precession (TrueFISP) magnetic resonance imaging (MRI) sequences for the detection and characterization of pulmonary abnormalities caused by coronavirus disease 2019 (COVID-19). Materials and Methods: In this retrospective single-center study, computed tomography (CT) and MRI scans of 20 patients with COVID-19 pneumonia were evaluated with regard to the distribution, opacity, and appearance of pulmonary lesions, as well as bronchial changes, pleural effusion, and thoracic lymphadenopathy. McNemar’s test was used in order to compare the COVID-19-associated alterations seen on CT with those seen on MRI. Results: Ground-glass opacities were better visualized on CT than on MRI (p = 0.031). We found no statistically significant differences between CT and MRI regarding the visualization/characterization of the following: consolidations; interlobular/intralobular septal thickening; the distribution or appearance of pulmonary abnormalities; bronchial pathologies; pleural effusion; and thoracic lymphadenopathy. Conclusion: Pulmonary abnormalities caused by COVID-19 pneumonia can be detected on TrueFISP MRI sequences and correspond to the patterns known from CT. Especially during the current pandemic, the portions of the lungs imaged on cardiac or abdominal MRI should be carefully evaluated to promote the identification and isolation of unexpected cases of COVID-19, thereby curbing further spread of the disease.

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2019 American Thoracic Society BEAR Cage Winning Proposal: Lung Imaging Using High-Performance Low-Field Magnetic Resonance Imaging

Cited by 16 publications

References 22 publications

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19

High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19

Oxygen‐enhanced functional lung imaging using a contemporary 0.55 T MRI system

Appearance of COVID-19 pneumonia on 1.5 T TrueFISP MRI

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