2018 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 36th Annual Report

Gummin, David D; Mowry, James B.; Spyker, Daniel A.; Brooks, Daniel E.; Beuhler, Michael C.; Rivers, Laura J; Hashem, Heba A.; Ryan, Mark L.

doi:10.1080/15563650.2019.1677022

Cited by 308 publications

(273 citation statements)

References 0 publications

Supporting

Mentioning

247

Contrasting

Unclassified

Order By: Relevance

“…Our overall in-hospital mortality rate was much higher than reported in other countries (Taiwan: 2.6%, other countries: 0.1-1.3%), as was our mortality rate from severe intoxication (Taiwan: 21.6%, other countries: 2-9%) (1, 2, 14, 15). The most likely reason is the higher proportion of severe intoxication events or greater severity of intoxication in our population (5)(6)(7)(8)(9)(10)(11)(12)(13)(16)(17)(18). Our mean ICU stay (3 days) and hospital LOS (7 days) was longer than reported in studies from The Netherlands and Hong Kong (ICU: 0-1.3 days; hospital LOS: 1-3 days) (14,18,19).…”

Section: Discussionmentioning

confidence: 47%

Incidence of Intoxication Events and Patient Outcomes in Taiwan: a Nationwide Population-based Observational Study

Chen

Chan

Su³

2020

Preprint

View full text Add to dashboard Cite

Background Intoxicated patients were frequently managed in the emergency departments (ED) with few studies at national level. The study aimed to reveal the incidence, outcomes of intoxications and trend in Taiwan.Methods Adults admitted to an ED due to an intoxication event between 2006 and 2013 were identified using the Taiwan National Health Insurance Research Database. The rate of intoxication and severe intoxication events, mortality rate, hospital length of stay (LOS), and daily medical costs of these patients were analyzed. Changes over time were analyzed using Joinpoint models. Subgroup analyses were used to assess the effect of sex, age, and presence of a prior psychiatric illness.Results A total of 20,371 ED admissions due to intoxication events were identified during the study period, and the incidence decreased with annual percentage change of 4.7% from 2006 to 2013. The mortality rate, hospital LOS, and daily medical costs were not decreased over time. Males and geriatric patients had more severe intoxication events, greater mortality rates, and greater daily medical costs. Patients with psychiatric illnesses had higher mortality rates and a longer hospital LOS, but lower daily medical expenses.Conclusion From 2006 to 2013, there was a decline in the incidence of ED admission for intoxication events in Taiwan. Males, geriatric patients, and those with psychiatric illnesses had greater risks for severe intoxication and mortality.

show abstract

Section: Discussionmentioning

confidence: 47%

Incidence of Intoxication Events and Patient Outcomes in Taiwan: a Nationwide Population-based Observational Study

Chen

Chan

Su³

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Using standardized data collection systems, each RPC records information about the exposed patient, the substances involved, the clinical effects and therapies, the level of HCF care provided, and the medical outcome. The AAPCC Annual Report provides definitions of these NPDS variables [26]. A common product database containing over 400,000 substances (Micromedex Poisindex V R System, IBM Watson Health, Greenwood Village, CO) is used to standardize the collection of substance information.…”

Section: Methodsmentioning

confidence: 99%

“…RPC staff follow up on cases that require medical management. Medical outcome (e.g., minor effect) is recorded after follow up is complete, if follow up is determined to not be required due to the low risk of the exposure, or if follow up cannot be completed [26]. After completion of follow up, the RPC closes the case.…”

Section: Methodsmentioning

confidence: 99%

Impact of product safety changes on accidental exposures to liquid laundry packets in children

Reynolds

Burnham

Delva-Clark

et al. 2020

Clinical Toxicology

View full text Add to dashboard Cite

Objectives: To evaluate the impact of the ASTM International (formerly American Society of Testing Materials) safety standard and associated product safety changes on accidental exposures to liquid laundry packets (LLPs) in children. Methods: The National Poison Data System was queried for reports of accidental exposures to LLPs in children <6 years old received from 01 July 2012 to 31 December 2018. In 2014, ASTM International began developing a standard specifying voluntary product changes to reduce the risk of LLP exposures in young children. Product changes were made between 2013 and 2016. Exposures were grouped into baseline, transition, and post periods based on the timing of the standard's implementation. Exposure counts and sales adjusted rates were compared between the baseline and post period for all exposures and exposures involving healthcare facility (HCF) evaluation, HCF admission, and major medical outcomes. Results: A total of 73,942 accidental exposures in children <6 years old were reported

show abstract

“…In 2018 the American Association of Poison Control Centers' has reported 23,138 case of exposure to hypoglycemic agents, 2058 of which are children less than 5 years old. Among these, biguanides represent the most used with 906 case 3 …”

Section: Introductionmentioning

confidence: 99%

Development of a new GC–MS/MS method for the determination of metformin in human hair

Arbouche

Batt²,

Raul

et al. 2020

Drug Testing and Analysis

View full text Add to dashboard Cite

Diabetes mellitus is one of the most important public health challenges. Metformin (1,1‐dimethylbiguanide) represents the “gold standard” for the treatment of diabetes mellitus type 2. Despite its important role in reducing mortality and morbidity in the diabetic population, metformin is associated with an increased risk of stroke. To document exposure to a drug, hair is considered to be the specimen of choice to complement blood and urine, since it provides historical detail of a subject's chronic exposure to drug(s). Measuring hair concentration of metformin can be important for forensic toxicologists investigating criminal poisoning or Munchausen's syndrome by proxy. In clinical toxicology, drug monitoring using hair to document metformin observance has not yet been described. To document the interest of hair analysis for metformin, the authors have developed and validated a method using a gas‐chromatography tandem mass spectrometry system and applied it to authentic hair obtained from 9 diabetic patients under daily treatment. The validation procedure demonstrated a LOD an LOQ of 1 and 100 pg/mg, respectively and acceptable linearity, repeatability and reproducibility. The hair of the 9 patients tested positive in the low ng/mg range with concentrations ranging from 0.3 to 3.8 ng/mg. It seems obvious, in comparison with other drugs, that metformin is badly incorporated into hair, as the daily dosage varied from 1 to 3 g. Although limited in the number of subjects, the study allowed to postulate a possible correlation between daily dose and concentration in dark hair, while for light hair no correlation was found.

show abstract

2018 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 36th Annual Report

Cited by 308 publications

References 0 publications

Incidence of Intoxication Events and Patient Outcomes in Taiwan: a Nationwide Population-based Observational Study

Incidence of Intoxication Events and Patient Outcomes in Taiwan: a Nationwide Population-based Observational Study

Impact of product safety changes on accidental exposures to liquid laundry packets in children

Development of a new GC–MS/MS method for the determination of metformin in human hair

Contact Info

Product

Resources

About