2017 SEOM guidelines: a multidisciplinary approach

Santaballa, Ana; Vera, Ruth

doi:10.1007/s12094-018-1830-7

Cited by 2 publications

(2 citation statements)

References 17 publications

(13 reference statements)

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“…It is possible that the progression of CUP parallels the primary tumor, and CUP metastases are an early event in tumor development. 5 In this case, the liver tumor grew rapidly over a short time, suggesting that the tumor was highly malignant. The clival metastasis was an early HCC progression event, and the metastasis grew more rapidly than the primary site.…”

Section: Discussionmentioning

confidence: 78%

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Clival Metastasis of Hepatocellular Carcinoma with an Initial Histopathological Diagnosis of Atypical Pituitary Adenoma

et al. 2019

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Histologically, hepatocellular carcinoma (HCC) and atypical pituitary adenoma are similar, posing a potential clinical problem. A 76-year-old woman, whose past medical history was significant for hepatitis C virus (HCV), positivity without liver cirrhosis was presented with abducens nerve (CN VI) palsy. Contrast-enhanced magnetic resonance imaging (MRI) showed a clival tumor with infiltration of the right cavernous sinus. Subtotal resection was performed using a right anterior petrosal approach. Histological diagnosis was pituitary adenoma. Thirty-four days after the operation, MRI imaging showed residual tumor growth without any liver masses on computed tomography (CT). The patient underwent a second operation using an endoscopic transnasal transsphenoidal approach. Histological examination of the specimen gave a positive reaction for α-fetoprotein. Repeat whole-body CT showed an enhanced liver mass. Based on these findings, the lesion was diagnosed as metastatic HCC. The patient died of liver failure 6 months later. In this case, tumor diagnosis was difficult because of the histological similarity of HCC and pituitary adenoma, and the fact that the clival tumor grew prior to presentation of the liver mass on CT. This case emphasizes the importance of comparing the pathological diagnosis with the patient's clinical course.

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Section: Discussionmentioning

confidence: 78%

“…When cancer is diagnosed as CUP, repeat CT, positron emission tomography, and serum tumor markers are recommended to find the true primary cancer. 5…”

Section: Discussionmentioning

confidence: 99%

Clival Metastasis of Hepatocellular Carcinoma with an Initial Histopathological Diagnosis of Atypical Pituitary Adenoma

et al. 2019

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Intestinal Microbiota Predicts Lung Cancer Patients at Risk of Immune-Related Diarrhea

Liu

Xiong

2019

Immunotherapy

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Previous studies showed that some patients after the treatment of anti-programmed cell death protein-1 (anti-PD-1) antibodies experienced immune-related diarrhea. In this study, we aim to explore the association between intestinal microbiota and immune-related diarrhea. Methods: We obtained the fecal samples of 26 advanced lung cancer patients before the first dose of anti-PD-1 antibodies. Results: Eight of 26 patients experienced diarrhea after the treatment of anti-PD-1 antibodies. At the phylum level, our study demonstrated that Bacteroidetes were higher in diarrhea-free (D-F) patients, while Firmicutes were lower. Bacteroides and Parabacteroides belonging to Bacteroidetes phylum and Phascolarctobacterium of Firmicutes phylum were more abundant in D-F patients. Whereas, Veillonella of Proteobacteria phylum was lower in D-F patients. Conclusion: Our study highlights that intestinal microbiota variation is correlated with the subsequent development of immune-related diarrhea.

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2017 SEOM guidelines: a multidisciplinary approach

Cited by 2 publications

References 17 publications

Clival Metastasis of Hepatocellular Carcinoma with an Initial Histopathological Diagnosis of Atypical Pituitary Adenoma

Clival Metastasis of Hepatocellular Carcinoma with an Initial Histopathological Diagnosis of Atypical Pituitary Adenoma

Intestinal Microbiota Predicts Lung Cancer Patients at Risk of Immune-Related Diarrhea

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