2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome

Shiboski, Caroline H.; Shiboski, Stephen; Séror, Raphaèle; Criswell, Lindsey A.; Labétoulle, Marc; Lietman, Thomas M.; Rasmussen, Astrid; Scofield, R. Hal; Vitali, Claudio; Bowman, Simon; Mariette, Xavier

doi:10.1136/annrheumdis-2016-210571

Cited by 1,019 publications

(579 citation statements)

References 36 publications

(25 reference statements)

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“…Included patients with inflammatory vasculopathies encompassed: (1) SLE, diagnosed according to the Systemic Lupus International Collaborating Clinics classification criteria22; (2) APS, diagnosed according to the Miyakis criteria23; (3) Behçet disease, diagnosed according to the International Study Group for Behçet's Disease24; (4) Sjögren disease, diagnosed according to the American College of Rheumatology/European League against Rheumatism criteria25; and (5) PACNS (imaging or biopsy proven), diagnosed according to Schuster et al13 …”

Section: Methodsmentioning

confidence: 99%

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

Maggi

Absinta

Grammatico

et al. 2018

Annals of Neurology

165

181

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ObjectivesIn multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the “central vein sign”) improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS‐mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions in MS versus systemic autoimmune diseases with CNS involvement and primary angiitis of the CNS (PACNS).MethodsIn 31 patients with inflammatory CNS vasculopathies and 52 with relapsing–remitting MS, 3‐dimensional T2*‐weighted and T2–fluid‐attenuated inversion recovery images were obtained during a single MRI acquisition after gadolinium injection. For each lesion, the central vein sign was evaluated according to consensus guidelines. For each patient, lesion count, volume, and brain location, as well as fulfillment of dissemination in space MRI criteria, were assessed.ResultsMS showed higher frequency of perivenular lesions (median = 88%) than did inflammatory CNS vasculopathies (14%), without overlap between groups or differences between 3T and 1.5T MRI. Among inflammatory vasculopathies, Behçet disease showed the highest median frequency of perivenular lesions (34%), followed by PACNS (14%), antiphospholipid syndromes (12%), Sjögren syndrome (11%), and systemic lupus erythematosus (0%). When a threshold of 50% perivenular lesions was applied, central vein sign discriminated MS from inflammatory vasculopathies with a diagnostic accuracy of 100%.InterpretationThe central vein sign differentiates inflammatory CNS vasculopathies from MS at standard clinical magnetic field strengths. Ann Neurol 2018;83:283–294

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Section: Methodsmentioning

confidence: 99%

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

Maggi

Absinta

Grammatico

et al. 2018

Annals of Neurology

165

181

View full text Add to dashboard Cite

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“…Patients were classified as pSS or non-pSS according to the recently published 2016 American College of Rheumatology-European League Against Rheumatism (ACR-EULAR) classification criteria 16. Routinely, all items of these criteria were assessed, including serology and histopathology.…”

Section: Methodsmentioning

confidence: 99%

Scoring hypoechogenic areas in one parotid and one submandibular gland increases feasibility of ultrasound in primary Sjögren’s syndrome

et al. 2017

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“…The heterogeneous presentation of SS, along with patients seeing different doctors for oral and eye complaints, makes diagnosis difficult and often delayed for several years. Although diagnostic criteria have changed over time with the improving knowledge of SS and now include a range of possible diagnostic benchmarks (10), a diagnostic tool that effectively describes the quality of saliva is lacking. As oral dryness is an early and prevalent symptom in SS (11), diagnosis of this symptom would improve the overall diagnosis of SS.…”

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confidence: 99%

Reduced Mucin-7 (Muc7) Sialylation and Altered Saliva Rheology in Sjögren's Syndrome Associated Oral Dryness

Chaudhury

Proctor

Karlsson

et al. 2016

Molecular & Cellular Proteomics

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Sjö gren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration and hypofunction of salivary and lacrimal glands. This loss of salivary function leads to oral dryness, impaired swallowing and speech, and increased infection and is associated with other autoimmune diseases and an increased risk of certain cancers. Despite the implications of this prevalent disease, diagnosis currently takes years, partly due to the diversity in patient presentation. Saliva is a complicated biological fluid with major constituents, including heavily glycosylated mucins MUC5B and MUC7, important for its viscoelastic and hydrating and lubricating properties. This study investigated Sjö gren's patient's perception of dryness (bother index questionnaires) along with the rheological, protein composition, and glycan analysis of whole mouth saliva and the saliva on the mucosal surface (residual mucosal saliva) to understand the properties that most affect patient wellbeing. Sjö gren's patients exhibited a statistically significant reduction in residual mucosal saliva, salivary flow rate, and extensional rheology, spinnbarkeit (stringiness). Although the concentration of mucins MUC5B and MUC7 were similar between patients and controls, a comparison of protein Western blotting and glycan staining identified a reduction in mucin glycosylation in Sjö gren's, particularly on MUC7. LC-MS/MS analysis of O-glycans released from MUC7 by ␤-elimination revealed that although patients had an increase in core 1 sulfation, the even larger reduction in sialylation resulted in a global decline of charged glycans. This was primarily due to the loss of the extended core 2 disialylated structure, with and without fucosylation. A decrease in the extended, fucosylated core 2 disialylated structure on MUC7, residual mucosal wetness, and whole mouth saliva flow rate appeared to have a negative and cumulative effect on the perception of oral dryness. The observed changes in MUC7 glycosylation could be a potential diagnostic tool for saliva quality and taken into consideration for future therapies for this multifactorial syndrome. Molecular & Cellular

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2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome

Cited by 1,019 publications

References 36 publications

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

Scoring hypoechogenic areas in one parotid and one submandibular gland increases feasibility of ultrasound in primary Sjögren’s syndrome

Reduced Mucin-7 (Muc7) Sialylation and Altered Saliva Rheology in Sjögren's Syndrome Associated Oral Dryness

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