2015 Beers Criteria and STOPP v2 for detecting potentially inappropriate medication in community-dwelling older people: prevalence, profile, and risk factors

Blanco-Reina, Encarnación; Valdellós, Jenifer; Aguilar-Cano, Lorena; García-Merino, María Rosa; Ocaña-Riola, Ricardo; Ariza-Zafra, Gabriel; Bellido, I.

doi:10.1007/s00228-019-02722-0

Cited by 29 publications

(24 citation statements)

References 52 publications

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“…Our study results are in accordance with the studies performed by Primejdie et al in 2012 and 2016, which highlighted that NSAIDs, benzodiazepines, zopiclone, and zolpidem are the pharmaceutical substances most frequently associated with safety concerns in ambulatory as well as in institutionalized patients [ 21 , 22 ]. In a study performed in Spain in 2019, where the two versions of the Beers criteria (2012 and 2015) and the two versions of the STOPP criteria (v.1, 2008 and v.2, 2015) were applied, benzodiazepines, proton-pump inhibitors, peripheral alpha-1 blockers, and NSAIDs were among the most common potentially inappropriate medications found [ 64 ]. Another study performed in Brazil in very old hospitalized patients emphasized (after applying the 2019 Beers criteria) that polypharmacy occurs in approximately 84.6% of cases and that the most commonly encountered PIMs are metoclopramide, omeprazole, regular insulin, and haloperidol [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western Part of Romania: Current Practices, International Recommendations, and Future Perspectives Regarding the Overuse and Misuse of Medicines

Buda

Prelipcean

Cristescu

et al. 2021

IJERPH

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The European Commission’s 2019 report regarding the state of health profiles highlighted the fact that Romania is among the countries with the lowest life expectancy in the European Union. Therefore, the objectives of the present study were to assess the current prescription habits of general physicians in Romania related to medicines taken by the elderly population for chronic conditions in both urban and rural setting and to discuss/compare these practices with the current international recommendations for the elderly (American—Beers 2019 criteria and European—STOPP/START v.2, 2015 criteria). A total of 2790 electronic prescriptions for chronic pathologies collected from 18 community pharmacies in the western part of Romania (urban and rural zones) were included. All medicines had been prescribed by general physicians. We identified the following situations of medicine overuse: 15% of the analyzed prescriptions involved the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for >2 weeks, 12% involved the use of a proton-pump inhibitor (PPI) for >8 weeks, theophylline was the bronchodilator used as a monotherapy in 3.17% of chronic obstructive pulmonary disease cases, and zopiclone was the hypnotic drug of choice for 2.31% of cases. Regarding the misuse of medicines, 2.33% of analyzed prescriptions contained an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II receptor blocker (ARB) for patients with renal failure in addition to vitamin K antagonists (AVKs) and NSAIDs in 0.43% of cases. Prescriptions for COX2 NSAIDs for periods longer than 2 weeks for patients with cardiovascular disorders accounted for 1.33% of prescriptions, and trihexyphenidyl was used as a monotherapy for patients with Parkinson’s disease in 0.18% of cases. From the included medical prescriptions, 32.40% (the major percent of 2383 prescriptions) had two potentially inappropriate medications (PIMs). Rural zones were found to be risk factor for PIMs. Decreasing the chronic prescription of NSAIDs and PPIs, discontinuing the use of hypnotic drugs, and avoiding potentially harmful drug–drug associations will have long term beneficial effects for Romanian elderly patients.

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Section: Discussionmentioning

confidence: 99%

Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western Part of Romania: Current Practices, International Recommendations, and Future Perspectives Regarding the Overuse and Misuse of Medicines

Buda

Prelipcean

Cristescu

et al. 2021

IJERPH

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“…Potentially inappropriate medications (PIMs) are classes of drugs whose risks may potentially outweigh their benefits [1]. Despite evidence of negative outcomes in older adults, healthcare practitioners continue to prescribe PIMs [2] to the extent that it has now become a public health concern because of its association with increased morbidity, hospitalization, and mortality [3][4][5][6]. The prevalence of PIM use in older adult populations in both developed and developing countries is very high.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Predictors of Potentially Inappropriate Medication Prescription Among Older Adults: A Cross-Sectional Study in the State of Qatar

Al-Dahshan

Kehyayan

2020

Drugs - Real World Outcomes

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Background Potentially inappropriate medications (PIMs) often lead to sub-optimal or poor health outcomes in older adults. Objective The objective of this study was to determine the prevalence and predictors of PIM prescription among older adults in Qatar. Patients and Methods This was a cross-sectional, retrospective study using data from the electronic medical records of Qatari patients (age ≥ 65 years) attending the 23 primary healthcare (PHC) centers in Qatar from April 1, 2017 to September 30, 2017. PIMs were identified based on the Beers 2015 criteria: (1) medications to avoid for many or most older adults, and (2) medications to be used with caution in older adults. Descriptive statistics were used to estimate the prevalence of PIM prescription; multivariable logistic regression analysis was performed to identify predictors of PIM prescription among the study population. Results 5639 older adults were included with a mean age of 72.8 (± 6.5) years; 53.8% were females. The prevalence of PIMs that should be avoided was 60.7%, with the most prevalent ones being gastrointestinal (84.2%), pain (49.9%), and central nervous system (10.4%) drugs. Most patients (61.1%) were prescribed one PIM, 26.9% two PIMs, and 12.0% three or more PIMs. The prevalence of PIMs that should be used with caution was 40.6%, with diuretics (83.1%), antidepressants (25.7%), and antiplatelets (18.3%) as the most prevalent drug classes. Multivariable logistic regression showed female gender, polypharmacy, and certain comorbidities to be significant predictors of PIM prescription. Conclusions Older adults attending Qatar’s 23 PHC centers are prescribed a high number of PIMs. Because of the high risk of PIM prescription, the practice of medication reconciliation should be strengthened and reinforced. Electronic supplementary material The online version of this article (10.1007/s40801-020-00220-9) contains supplementary material, which is available to authorized users.

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“…According to previous research, older people (aged 65 and over) took an average of 6.5–7.5 drugs, and the proportion of those who took 5 or more drugs was 44.1–67.4% [ 9 , 10 ]. The prevalence of potentially inappropriate medication (PIM) use based on the Beers Criteria was 70–80% [ 11 , 12 ], which was higher than that in the United States (39.9–56.6%) [ 13 , 14 ] and Europe (24.1–68.6%) [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Patient- and Prescriber-Related Factors Associated with Potentially Inappropriate Medications and Drug–Drug Interactions in Older Adults

Jang

Jeong

2021

JCM

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We aimed to evaluate the prevalence of potentially inappropriate medication (PIM) use and drug–drug interactions (DDIs) in older adults and their associated factors. This cross-sectional study used National Health Insurance data of older adults in South Korea. The 2015 AGS Beers Criteria were used to classify PIM use and DDIs. The associations of PIM use and DDIs with patient- and prescriber-related factors were evaluated using multiple logistic regression. Of the older adults who received at least one outpatient prescription (N = 1,277,289), 73.0% and 13.3% received one or more prescriptions associated with PIM use or DDIs, respectively. Chlorphenamine was most commonly associated with PIM, followed by diazepam. Co-prescriptions of corticosteroids and NSAIDs accounted for 82.8% of DDIs. Polypharmacy and mainly visiting surgeons or neurologists/psychiatrists were associated with a higher likelihood of prescriptions associated with PIM use or DDIs. Older age, high continuity of care (COC), and mainly visiting a hospital were associated with a lower likelihood of PIM use or DDIs. Prescriptions associated with PIM use and DDIS were more frequent for low COC patients or those who mainly visited clinics; therefore, patients with these characteristics are preferred intervention targets for reducing prescriptions associated with PIM use and DDIs.

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2015 Beers Criteria and STOPP v2 for detecting potentially inappropriate medication in community-dwelling older people: prevalence, profile, and risk factors

Cited by 29 publications

References 52 publications

Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western Part of Romania: Current Practices, International Recommendations, and Future Perspectives Regarding the Overuse and Misuse of Medicines

Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western Part of Romania: Current Practices, International Recommendations, and Future Perspectives Regarding the Overuse and Misuse of Medicines

Prevalence and Predictors of Potentially Inappropriate Medication Prescription Among Older Adults: A Cross-Sectional Study in the State of Qatar

Patient- and Prescriber-Related Factors Associated with Potentially Inappropriate Medications and Drug–Drug Interactions in Older Adults

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