Abstract:Adelylyl cyclase 8(AC8) is a brain specific cyclase activated only by calcium. Therefore its activity has been associated with plasticity process underlying learning and memory. AC8 knockout(KO) mice show impaired stress-induced anxiety. Here we try to find whether AC8 is involved in hypothalamus-hypophysis-axis(HPA) regulation and if it influences intracellular signaling of gluccocorticoids in the hippocampus.First, serum samples were harvest from 8 AC8 KO and 8 wild type(WT) mice at basal, eve, 30 and 120 mi… Show more
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