2013 AAFP Feline Vaccination Advisory Panel Report

Three-year duration of immunity for feline herpesvirus and calicivirus evaluated in a controlled vaccination-challenge laboratory trial

“…The frequency of cats with ulcers was significantly lower in 8 the vaccinated group than in the control (23% in vaccinated group versus 70% in control group, 9 Fisher's exact test, p=0.04). When the average FHV clinical scores of the cats that displayed 10 FCV-induced ulcers were compared to the average scores of those that did not, no significant 11 difference could be found. The average FHV clinical score of the cats that displayed FCV- 12 induced ulcers is 56.7 (n=10) whereas the score of the cats that had no ulcers is 53.7 (n=13).…”

“…Along 8 with feline parvovirus (FPV), FHV and FCV are considered core vaccine components that all cats 9 should receive. 10 In the last decade, annual revaccination of pets has been challenged, especially in cats, where 11 injection-site sarcomas raised the question of the benefit/risk of annual revaccination. Three One vaccinated cat was found dead approximately one year after the annual booster injection.…”

“…Considering those cats with 6 clinical disease (all cats with a global clinical score > 1), the clinical score of vaccinated cats was 7 lower than in controls (median clinical score was 8 versus 21, respectively) showing a 8 statistically significant reduction in the severity of the disease (Wilcoxon-Mann-Whitney test, 9 p=0.01). 10 All cats including those that did not show clinical signs shed virus after challenge, validating 11 thereby the virulent challenge. No difference of shedding was observed between groups.…”

“…Three-year DOI was demonstrated by challenging the animals with virulent strains of FHV and11 FCV. Although serologic test have been claimed to predict resistance to FHV and FCV (Lappin12 et al, 2002), antibody titres are not strictly correlated with protection and cannot be used to 13 demonstrate DOI.…”

Small Nondomestic Felids in Veterinary Practice

“…67 Current guidelines recommend vaccination for FVRCP below the right elbow, FeLV below the left stifle, and rabies below the right stifle, as low on the leg as possible. 68 Vaccination in the tip of the tail has also recently been reported as safe and effective. 69 …”