2011 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report

Bronstein, Alvin C.; Spyker, Daniel A.; Cantilena, Louis R.; Rumack, Barry H.; Dart, Richard C.

doi:10.3109/15563650.2012.746424

Cited by 379 publications

(314 citation statements)

References 3 publications

Supporting

Mentioning

285

Contrasting

Unclassified

Order By: Relevance

“…In 2011, the National Poison Data System (NPDS) reported over 2.3 million human exposure calls to regional poison centers in the USA with 2765 deaths (1.1 %) [1]. Of the fatalities reported by NPDS, the majority (1689, 85 %) were due to pharmaceuticals [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC)

et al. 2015

View full text Add to dashboard Cite

Although there have been many developments related to specific strategies for treating patients after poisoning exposures, the mainstay of therapy remains symptomatic and supportive care. One of the most aggressive supportive modalities is extracorporeal membrane oxygenation (ECMO). Our goal was to describe the use of ECMO for toxicological exposures reported to the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (Tox-IC). We performed a retrospective review of the ACMT ToxIC Registry from January 1, 2010 to December 31, 2013. Inclusion criteria included patients aged 0 to 89 years, evaluated between January 2010 through December 2013, and received ECMO for toxicological exposure. There were 26,271 exposures (60 % female) reported to the ToxIC Registry, 10 (0.0004 %) received ECMO: 4 pediatric (< 12 years), 2 adolescent (12-18 years), and 4 adults (>18 years). Time of initiation of ECMO ranged from 4 h to 4 days, with duration from 15 h to 12 days. Exposures included carbon monoxide/smoke inhalation (2), bitter almonds, methanol, and several medications including antihistamines (2), antipsychotic/ antidepressant (2), cardiovascular drugs (2), analgesics (2), sedative/hypnotics (2), and antidiabetics (2). Four ECMO patients received cardiopulmonary resuscitation (CPR) during their hospital course, and the overall survival rate was 80 %. ECMO was rarely used for poisoning exposures in the ACMT ToxIC Registry. ECMO was utilized for a variety of ages and for pharmaceutical and non-pharmaceutical exposures. In most cases, ECMO was administered prior to cardiovascular failure, and survival rate was high. If available, ECMO may be a valid treatment modality.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Of the fatalities reported by NPDS, the majority (1689, 85 %) were due to pharmaceuticals [1]. The severity of poisonings has steadily increased over the past 30 NPDS annual reports, and the CDC reports that poisoning has recently become the leading cause of injury-related death [2,3].…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC)

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Substances usually identified as the causative agent in fatal poisoning in children less than 5 years of age are divided into pharmaceutical and non-pharmaceutical agents, in similar proportion of incidence [2]. The most frequent pharmaceutical agents in fatal poisoning are opioid analgesics, cardiovascular drugs and paracetamol [3].…”

Section: Introductionmentioning

confidence: 99%

“…Unlike fatal poisoning, nonfatal poisoning is rather common among children. According to the Annual Reports of the American Association of Poison Control Centers' for years 2010 and 2011, over 1 million of poison exposures among children younger than six years of age are reported in United States every year [2,4]. A great majority of poisonings in this age group are unintentional and occur at home (90%) [2,4].…”

Section: Introductionmentioning

confidence: 99%

Death by band-aid: fatal misuse of transdermal fentanyl patch

2015

View full text Add to dashboard Cite

We present a case of fatal intoxication by the application of a transdermal fentanyl patch upon a superficial bleeding abrasion of a 2-year-old girl. The grandmother discovered the body of the child in bed at approximately 7 a.m. External examination revealed a properly developed, nourished and hydrated child, with some vomit in the nostrils and inside the mouth. There was no evidence of trauma besides small contusions and abrasions on knees, with a patch placed over the largest abrasion. Closer inspection revealed that this was transdermal fentanyl patch.Internal examination and microscopic analysis revealed regurgitation of stomach content, cerebral and pulmonary edema and liver congestion. Toxicology analysis revealed trace levels of fentanyl in the blood just above the limit of detection (2 ng/mL), while concentrations in the urine, liver and kidney were approximately 102, 28 and 10 ng/mL, respectively. Investigation discovered that the child injured her knee while playing the evening before. The grandmother applied the patch to cover the injury, unaware that she had used a fentanyl transdermal patch instead of simple band-aid.Although fatal intoxications are uncommon among young children in high-income countries, it is of major interest to raise awareness of such events especially since a great majority of these are preventable. The presented case points at the need for more thorough education of users and more strict rules in prescribing and handling of this potent medicine. As well, we find this case to be a useful contribution to the evaluation of postmortem fentanyl concentrations in fatal intoxication in a small child.

show abstract

“…Collectively, PCs receive more than four million exposure and information calls annually [2]. All calls are electronically reported to NPDS, a near real-time surveillance system maintained by the American Association of Poison Control Centers (AAPCC) and CDC.…”

Section: Introductionmentioning

confidence: 99%

On the Role of Poison Centers in Radiation Emergency Preparedness and Response Activities: Findings of the “Radiation Emergencies Public Health Roundtable” (Atlanta, GA—August 2012)

Pomerleau¹,

Schauben

Bronstein

et al. 2013

J. Med. Toxicol.

View full text Add to dashboard Cite

2011 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report

Cited by 379 publications

References 3 publications

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC)

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC)

Death by band-aid: fatal misuse of transdermal fentanyl patch

On the Role of Poison Centers in Radiation Emergency Preparedness and Response Activities: Findings of the “Radiation Emergencies Public Health Roundtable” (Atlanta, GA—August 2012)

Contact Info

Product

Resources

About