2010: A Small Space Odyssey with Luminescent Molecules

Silva, A. Prasanna de

doi:10.1002/ijch.201000063

Cited by 5 publications

(1 citation statement)

References 119 publications

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“…Such a limitation was first overcome by the photoinduced electron transfer (PET) luminescent sensors . In this case, a luminescence self-quenching process, due to a photoinduced electron transfer from an electron rich moiety to the fluorogenic unit, is built into the sensor.…”

Section: Introductionmentioning

confidence: 99%

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

et al. 2015

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By exploiting a magnetization transfer between monolayer-protected nanoparticles and interacting analytes, the NMR chemosensing protocol provides a general approach to convert supramolecular receptors into chemosensors via their conjugation with nanoparticles. In this context, the nanoparticles provide the supramolecular receptor not only with the "bulkiness" necessary for the NMR chemosensing approach but also with a different selectivity as compared to the parent receptor. We here demonstrate that gold nanoparticles of 1.8 nm core coated with a monolayer of 18-crown-6 ether derivatives can detect and identify protonated primary amines in methanol and in water, and even discriminate between two biogenic diamines that are selectively detected over monoamines and α-amino acids.

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Section: Introductionmentioning

confidence: 99%

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

et al. 2015

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Design principles and action of molecular logic gates

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2014

Russ Chem Bull

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Single Fluorescent Probe Responds to H₂O₂, NO, and H₂O₂/NO with Three Different Sets of Fluorescence Signals

et al. 2011

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Hydrogen peroxide (H(2)O(2)) acts as a signaling molecule in a wide variety of signaling transduction processes and an oxidative stress marker in aging and disease. However, excessive H(2)O(2) production is implicated with various diseases. Nitric oxide (NO) serves as a secondary messenger inducing vascular smooth muscle relaxation. However, mis-regulation of NO production is associated with various disorders. To disentangle the complicated inter-relationship between H(2)O(2) and NO in the signal transduction and oxidative pathways, fluorescent reporters that are able to display distinct signals to H(2)O(2), NO, and H(2)O(2)/NO are highly valuable. Herein, we present the rational design, synthesis, spectral properties, and living cell imaging studies of FP-H(2)O(2)-NO, the first single-fluorescent molecule, that can respond to H(2)O(2), NO, and H(2)O(2)/NO with three different sets of fluorescence signals. FP-H(2)O(2)-NO senses H(2)O(2), NO, and H(2)O(2)/NO with a fluorescence signal pattern of blue-black-black, black-black-red, and black-red-red, respectively. Significantly, we have further demonstrated that FP-H(2)O(2)-NO, a single fluorescent probe, is capable of simultaneously monitoring endogenously produced NO and H(2)O(2) in living macrophage cells in multicolor imaging. We envision that FP-H(2)O(2)-NO will be a unique molecular tool to investigate the interplaying roles of H(2)O(2) and NO in the complex interaction networks of the signal transduction and oxidative pathways. In addition, this work establishes a robust strategy for monitoring the multiple ROS and RNS species (H(2)O(2), NO, and H(2)O(2)/NO) using a single fluorescent probe, and the modularity of the strategy may allow it to be extended for other types of biomolecules.

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2010: A Small Space Odyssey with Luminescent Molecules

Cited by 5 publications

References 119 publications

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

Design principles and action of molecular logic gates

Single Fluorescent Probe Responds to H₂O₂, NO, and H₂O₂/NO with Three Different Sets of Fluorescence Signals

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2010: A Small Space Odyssey with Luminescent Molecules

Cited by 5 publications

References 119 publications

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted “NMR Chemosensing”

Design principles and action of molecular logic gates

Single Fluorescent Probe Responds to H2O2, NO, and H2O2/NO with Three Different Sets of Fluorescence Signals

Contact Info

Product

Resources

About

Single Fluorescent Probe Responds to H₂O₂, NO, and H₂O₂/NO with Three Different Sets of Fluorescence Signals