Purpose of this study was to investigate the effect of music therapy on vital signs, anxiety, cortisol, and pain of Cataract Surgery Patients in elderly. Non equivalent control group pre-post test design was adopted. The number of subjects consists of 41 elderly having cataract surgery, 21 in the experimental group and 20 in the control group. Data were analyzed by x 2 test, Fisher's exact test, independent sample t-test, andMann-Whitney U test. Results were: 1) there was no difference between two groups in their vital signs changes 2) anxiety, cortisol in the saliva, and pain of the experimental group decreased more significantly than those of the control group. This study confirmed the ability of music therapy to relieve pain and anxiety in cataract surgery, and suggested that music therapy could be used effectively in various interventions for the elderly.